2. Electrical Activity of the Heart Flashcards
What is the sarcolemma?
Membrane which surrounds the heart cells which is invaginated
What is the sarcoplasmic retriculum?
Big calcium store which is needed to trigger excitation
What type of junctions are found between cardiac cells and what do they allow?
Gap junctions; allow electrical connection and passage of signalling molecules from one cell to the next (depolarisation and APs pass from cell to cell)
What ensures a physical connection between adjacent cardiac cells?
desmosomes
What is the structure involving desmosomes and gap junctions called?
Intercalated discs
What is the difference between AP in skeletal and cardiac muscles?
AP in cardiac muscles is much longer and larger
What is needed in cardiac cells to create longer APs?
Bigger influx of Ca from outside into the cell
What contraction is created from ca entry into the cardiac cell?
sub-maximal contraction
Is there tetanus in cardiac muscle?
No tetanus; no prolonger contraction of muscle by prolonged repeated stimuli (tetanus exists in skeletal muscle)
What is the refractory period like in cardiac muscle cells?
Long refractory period; cardiac muscle has to relax before it can contract again
What are contractions in cardiac cells like?
they are GRADED contractions (whereas skeletal muscle ones are all or none)
What is the force generated by cardiac muscle proportional to?
Proportional to number of cross bridges that are active which is determined by how much Ca is bound to troponin
What is the contraction of cardiac muscle dependent on? (2)
- cytosolic Ca concentration
2. sarcomere length at the beginning of contraction (initial length of muscle fibre)
What is the main difference in action potentials between skeletal and cardiac cells?
In cardiac cells;
- rapid depolarization occurs because of Na entry
-steep repolarization occurs because of K leaving
BUT! In cardiac cells the main difference is that there is the lengthening of the AP due to Ca entry
Cardiac muscle cells act as one functioning cell- what is this called?
functional syncytium
How are cardiac cells electrically connected?
via gap junctions
How are cardiac cells physically connected?
via desmosomes
What is the AP of a cardiac muscle in terms of msec compared to skeletal muscle?
Cardiac muscle AP= 250msec (much longer AP)
Skeletal muscle AP= 2msec
What is the refractory period of cardiac muscle?
Long so cannot exhibit tetanic contraction
What regulates contraction force on a molecular level?
Ca entry from outside cell (can be used to vary strength of contraction)
What do pacemaker cells have that other cardiac cells don’t in terms of potentials?
they have an unstable resting membrane potential
Why is prevention of having tetanus important in cardiac cells? Why is it NOT needed?
Because cardiac muscles must relax between contractions so ventricles can fill with blood
What is tetanus?
Sustained contraction (when a series of APs occur in rapid successions)
Why can’t tetanus never occur in cardiac cells?
Because longer AP means refractory period and contraction end almost simultaneously (by the time the second AP takes place, the myocardial cell has almost completely relaxed)
Can summation occur in cardiac cells?
NO
What is the RMP of non-pacemaker cells? What are they described as?
RMP= -90mVP
Very stable cells
What is the RMP in pacemaker cells? What are they described as?
RMP= -60mVP
Unstable
Why is the potential for pacemaker cells called “pacemaker potential” rather than RMP?
Because it never rests at a constant value
What is the main difference between depolarisation between non-pacemaker and pacemaker cells?
In pacemaker cells depolarisation is due to additional Ca channels opening while in non-pacemaker cells this is due to Na channels opening
What creates an RMP in normal non-pacemaker cells?
leaky K channels
Describe the 4 steps in non-pacemaker APs by referring to its basic electrophysiology.
- Resting Membrane Potential
- Initial depolarisation
- Plateau
- Repolarisation
What occurs in step 1; resting membrane potential?
High resting PK+ (leaky K channels)