2. Antimycobacterials

Question 1

Drugs which are antimycobacterials

Answer 1

• Rifampicin
• Isoniazid
• Pyrazinamide
• Ethambutol

Question 2

Antimycobacterials which are hepatotoxic

Answer 2

Rifampicin, Isoniazid, Pyrazinamide EXCEPT Ethambutol.

Patients should report signs of a liver disorder such as persistent vomiting and abdominal pain, urine and jaundice.

Question 3

Antimycobacterials that cause peripheral neuropathy

Answer 3

Isoniazid, therefore should be co-prescribed with pyridoxine to prevent this.
Patients must avoid tyramine and histamine-rich foods

Question 4

Antimycobacterials that cause visual deterioation

Answer 4

Ethambutol. Patients must stop and report signs of deterioation in their vision

Question 5

Rifampicin interactions

Answer 5

Rifampicin is an enzyme inducer so interacts with hormal contraceptives

Question 6

Rifampicin counselling/label

Answer 6

Colours bodily fluids orange