2/18: Drug Syndromes-- Chart Summary

Question 1

SS + Rx history

Answer 1

pro-serotonergic drug

Question 2

SS + time for condition to develop

Answer 2

<12 hrs

Question 3

SS + vital signs

Answer 3

HTN, tachycardia, tachypnea, hyperthermia (>41.1˚C)

Question 4

SS + pupils/mucosa/skin

Answer 4

mydriasis, sialorrhea (excessive drooling), diaphoresis

Question 5

SS + bowel sounds

Answer 5

hyperactive

Question 6

SS + neuromuscular tone

Answer 6

inc, predominately in lower extremities

Question 7

SS + neuromuscular reflexes

Answer 7

hyperreflexia clonus (unless masked by inc muscle tone)

Question 8

SS + mental status

Answer 8

agitation, coma

Question 9

anticholinergic “toxidrome” + Rx Hx

Answer 9

anti-cholinergic agent

Question 10

anticholinergic “toxidrome” + time for condition to develop

Answer 10

<12 hrs

Question 11

anticholinergic “toxidrome” + vital signs

Answer 11

HTN (mild), tachycardia, tachypnea, hyperthermia (<38.8˚C)

Question 12

anticholinergic “toxidrome” + pupils/mucosa/skin

Answer 12

mydriasis / dry erythema hot and dry to touch

Question 13

anticholinergic “toxidrome” + bowel sounds

Answer 13

dec or absent

Question 14

anticholinergic “toxidrome” + neuromuscular tone

Answer 14

normal

Question 15

anticholinergic “toxidrome” + neuromuscular reflexes

Answer 15

normal

Question 16

anticholinergic “toxidrome” + mental status

Answer 16

agitated, delirium

Question 17

neuroleptic malignant syndrome + Rx Hx

Answer 17

dopamine antagonist

Question 18

neuroleptic malignant syndrome + time for condition to develop

Answer 18

1-3 days

Question 19

neuroleptic malignant syndrome + vital signs

Answer 19

HTN, tachycardia, tachypnea, hyperthermia (>41.1˚C)

Question 20

neuroleptic malignant syndrome + pupil/mucosa/skin

Answer 20

normal / sialorrhea / pallor, diaphoresis

Question 21

neuroleptic malignant syndrome + bowel sounds

Answer 21

normal or dec

Question 22

neuroleptic malignant syndrome + neuromuscular tone

Answer 22

“lead-pipe” rigidity present in all muscle groups

Question 23

neuroleptic malignant syndrome + neuromuscular reflexes

Answer 23

bradyreflexia

Question 24

neuroleptic malignant syndrome + mental status

Answer 24

stupor, alert mutism, coma

Question 25

malignant hyperthermia + Rx Hx

Answer 25

inhalational anesthesia (INHA)

Question 26

malignant hyperthermia + time for condition to develop

Answer 26

30 min - 24 hr after admin of INHA or succinylcholine

Question 27

malignant hyperthermia + vital signs

Answer 27

HTN, tachycardia, tachypnea, hyperthermia (can be as high as 46˚C)

Question 28

malignant hyperthermia + pupils/mucosa/skin

Answer 28

normal / normal / mottled appearance, diaphoresis

Question 29

malignant hyperthermia + bowel sounds

Answer 29

decreased

Question 30

malignant hyperthermia + neuromuscular tone

Answer 30

"rigor mortis" like rigidity

Question 31

malignant hyperthermia + neuromuscular reflexes

Answer 31

hyporeflexia

Question 32

malignant hyperthermia + mental status

Answer 32

agitation