195b RE pharm 2 - female Flashcards
GnRH secretion in females
one pulse/hour
slower in luteal phase due to progrestin
gonadorelin
GnRH agonst - ovulation for infertility
leuprodie
endometrosis and uterine fibroids
palliation of breast carcinoma
SE - vaginal dryness, atrophy; bone loss in both female and male
E and P receptors
ER a - sexual development and repro
ER b- unknown
PR a and b isoforms too
uterine endometrium, cervix, vagina, mammary - E vs P
uterus
E = proliferation
P = secretion
cervix
E= watery mucus (allows sperm)
P = viscous mucus
vagina
E=thickening
mammary gland
E=ductal grwoth
P=alveolar growth (prep for lactation)(
E and P on kidney
kidney - E increases NA and water retention
liver - E increases HDL, clotting factors, steroids, decrease LDL
CT - E growth, epiphyseal closure, decreases aging changes
CNS - E nausea, P increases body Temp
receptrs - E increases P receptors, P decrease E receptors
drug interactions -
both E and P bind proteins – affects other drugs
broad spectrum antibiotics can affect E – E is conjugated into bile, hydrolyzed by bacteria in gut; antibiotics block this recirculation
E uses
replacement rx
androgen antagonist - PC, acne, hirsutism
contraception
P uses
dysfunctional uterine bleeding - excessive E with low P
endometriosis/endometrial cancer
prevents premature labor
OCPs
E + P use
hormone replacement in menopause (if intact uterus)
dysmenorrhea
supress lactation
limit excessive growth
OCPs
E agents
17b-estradiol - normal E
estradiol benzoate - syn, long acting
ethinyl estradiol - oral syn
conjugated equine estrogen - oral
diethylstilbesterol - oral, nonsteroid, carcinogenic
soy, phenols, flavenoids, phthalate plasticizers
estrogenic agents
prosterone agents
progesterone
medtroxyprogesterone - oral, depot
norethindrone, lveonorgestrel - syn, oral
E SE
nausea Na retention, edema - weight gain, HTN breast tenderness endometial hyperplasia thromboembolism increased breast cancer in post-menopause
P SE
na retention, edema – weight gain
depression
