183 female endo II

Question 1

menstrual cycle

Answer 1

luteum - sturcutre after ovulation from theca and granulasome cells - LH secretion causes it to secrete P

P slows GnRH pulse generator –> causes FSH rise and LH drop

FSH causes follicle growth and inhibit B –> starts to favor LH over FSH

surge of LH at midcycle –> ovulation

Question 2

oligomen vs amen.

Answer 2

oligo - long cycles

amen - absence for ~3 months (primary vs secondary - primary never have it, secondary - loss it)

Question 3

functional hypothalamic amenorrhea (FHA)

Answer 3

wiring is fine – alter nt’s on GnRH –> low GnRH pulses –> low E and P –> stress fractures

high opiods, low leptin
stress (college, military service)
nutrition

Question 4

pituitary disorders causing amen.

Answer 4

anything that destroys pituitary

hyperprolactinemia –> increases dopamine –> inhibits GnRH secretion

Question 5

ovarian disorders causing amen.

Answer 5

destruction, iatrogenic (chemo) –> premature ovarian insufficiency (POI), idiopathic

high LH/FSH and low inhibin/E2

Question 6

hyperandrogenic chronic anovulation –> irregular menses

Answer 6

polycystic ovary syndrome w/ insulin resistance + others

increased GnRH and LH pulses –> increased androgen, masculinzation + aromatasized into estrogen –> build up uterus but no P to shed –> neoplasms of uterus

Question 7

PCOS

Answer 7

hyperandrogenism
chronic anovulation - irregular periods
insulin resistance –> insulin increases LH and androgen releaseq
high risk for DM2

Question 8

what is the most sensitive to ovary health?

Answer 8

FSH

high = gonad issue
low = hypothalamus or pituitary issue