19.1

Question 1

study of genomics

Answer 1

-early efforts focused on isolating and sequencing genes
-genomics integrates classical and molecular genetics to better understand genomes
*mapping genomes
*sequencing genomes
*genome annotation
*genome analysis

Question 2

mapping genomes

Answer 2

-help navigate through a genome
-may be high or low resolution
-two main types of maps
*genetic maps
*physical maps

Question 3

genetic maps

Answer 3

-recombination frequency and linkage analysis
-relative locations

Question 4

physical maps

Answer 4

-precise location
-nucleotide-level resolution

Question 5

types of physical maps

Answer 5

-use landmarks within the DNA sequence
*restriction sites
*small segments of DNA
*measure distance in base-pairs
–restriction maps: map cut sites
–chromosome maps: utilize staining techniques

Question 6

sequence-tagged site (STS) maps

Answer 6

combine large high resolution and ability to view large pieces of DNA at glance
-STS:
small stretch of unique DNA (amplified with PCR)
allows researchers to identify and organize DNA fragments