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BECOM II EXAM V > 182 Principles Of Drug Interactions > Flashcards

182 Principles Of Drug Interactions Flashcards

1
Q

What happens when penicillin and amingoglycides are mixed prior to IV administration

A

They form a ppt

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2
Q

What occurs when propranolol and cardiac depressants are mixed

A

Additive effects

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3
Q

What happens when nirtoglyceran and phosphodiesterase inhibitors are mixed

A

Synergistic effects

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4
Q

What is the effect when EPI and histamine are mixed

A

Opposing effects

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5
Q

What drugs are altered by pH

A

H2 blockers (Cimetidine, ranitidine) and Ketoconazole (requires low pH for absorption)

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6
Q

What drugs are altered by bacterial flora

A

Antibiotics and digoxin

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7
Q

What elements chelate tetracycline

A

Aluminum, calcium, and iron

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8
Q

What binds digoxin and prevents absorption

A

Cholestryramine

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9
Q

Atineoplastic drugs and digoxin cause

A

Drug induced mucosal damage

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10
Q

What drug increases the absorption of cyclosporine

A

Antiemetic (metclopramide)

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11
Q

What drug displaces warfarin from albumin, increasing anti-coagulation activity

A

Bucolome

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12
Q

What drugs induce CYP1A2 and CYP2C9

A

Barbiturates, carbamazepine, and rifampin (increases warfarin)

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13
Q

What drug induces CYP1A2

A

Theophylline

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14
Q

What drug induces CYP2C9

A

Phenytoin

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15
Q

What drug inhibits CYP1A2

A

Cimetidine (prevents metabolism of Benzos, warfarin, theophylline, phenytoin)

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16
Q

Probenecid inhibits weak organic tubular secretion of

A

Penicillin

17
Q

What are the effects and active ingredients of St. John’s Wort

A

Anti-depressant and wound healing

Napthodianthrones, flavonoids, hyperforin

18
Q

What is the active constituents of ginkgo biloba and what is major DDI

A

Terpene lactose and ginkgo flavones glycosides

DDI warfarin

19
Q

Many recreational drugs are metabolized by

A

CYP3A4

20
Q

What is the ketoconazole-cyclosporine interaction

A

Used as immunosuppressant for transplantation

Ketoconazole is a potent CYP3A4 inhibitor

21
Q

Ritonavir inhibits

A

CCYP3A4

22
Q

What are the main platers of grapefruit Joyce’s

A 
Naringin and furancoumarin
Inhibits CYP3A4 (statins)

BECOM II EXAM V (9 decks)

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