141 & 144 Tissue renewal, regen, repair

Question 1

what are the three tissue types

Answer 1

labile-readily regenerate
stabile-limited regeneration
permanent-no regeneration

Question 2

what are the three purposes of ECM

Answer 2

mechanical support
control proliferation
scaffolding for tissue renewal

Question 3

what are the 2 basic forms of ECM

Answer 3

interstitial and BM

Question 4

what are the components of interstitial matrix

Answer 4

fibrillary collagens, elastins, proteoglycans

Question 5

what are the three components of basement membrane

Answer 5

collagen type IV, laminen, proteoglycan

Question 6

what type of GF bind ERBB

Answer 6

EGF and TGF-alpha

Question 7

what type of GF is responsible for angiogenesis

Answer 7

VEGF

Question 8

what gf is assembled with proteoglycans and produced by MMP protease

Answer 8

FGF

Question 9

what type of growth fact brakes inflammation, and are secreted as inactive precursor for MMP

Answer 9

TFG-beta

Question 10

what does platelet degranulation release

Answer 10

PDGF and TGF-B

Question 11

what does PDGF recruits

Answer 11

macrophages and fibroblasts

Question 12

what does macrophages release

Answer 12

MMPs (along with plasmin), VEGF adn FGF

Question 13

what liberates and activates GF

Answer 13

MMPs

Question 14

what vitamin is important for fibrillar collagens

Answer 14

vitamin C

Question 15

what do glucocorticoids inhibit that leads to weakness of scar formation

Answer 15

TGF-B