18/02

Question 1

What labatory finding is most consistent with beta thalassaemia major?

Answer 1

Raised HbA2

Question 2

What cancer is downs syndrome associated with?

Answer 2

Acute lymphocytic leukaemia

Question 3

What is a cause of B12 deficiency and how can it present?

Answer 3

Terminal ileum resection- Crohns disease as this is where B12 is absorbed

Can present with glossitis

Question 4

What medication decreases the number of sickle crises?

Answer 4

Hydroxycarbamide

Question 5

What is the threshold for platelet transfusion?

Answer 5

Platelet count <100

Or >100 and signs of bleeding

Question 6

What is a factor of poor prognosis in Hodgkins lymphoma?

Answer 6

Presence of B symptoms e.g. weight loss and night sweats

Question 7

What are features of beta thalassaemia trait?

Answer 7

Disproportionate microcytic anaemia

Iron is very low compared to Hb

Question 8

What is being prevented when having a back of irradiated RBC?

Answer 8

Graqft versus host disease

Question 9

What are features of sequestration crises in sickle cell disease?

Answer 9

Splenomegaly causing abdo pain

Anaemia

Question 10

What is the management of acute haemolytic transfusion reaction?

Answer 10

Stop the transfusion and give IV fluids