03/02

Question 1

What is the typical picture of anaemia of chronic disease?

Answer 1

Normocytic anaemia
Low iron
Low TIBC
Raised ferritin

Question 2

What happens to the ALP in CML?

Answer 2

It is decreased

Question 3

What is the initial treatment of choice for CLL?

Answer 3

Fludarabine, cyclophosphamide and rituximab

Question 4

What are features of beta thalassaemia trait?

Answer 4

Mild hypochromic, microcytic anaemia

• the iron level is normally much lower than Hb
• Hb rarely drops below 90

Raised Haemoglobin A2

Question 5

What are symptoms of polycythaemia vera?

Answer 5

Pruritis- worse after hot showers or baths
Tingling, burning and numbness in arms, hands and feet
Headaches and lethargy
Splenomegaly
Elevated Hb on FBC

Question 6

What is the management of polycythaemia vera?

Answer 6

Venesection to remove Hb
-initially done weekly but once under control can be done very 6-12wks

Aspiring to reduce risk of thrombotic events

Question 7

What cancer can myeloidysplasia predispose to?

Answer 7

Acute Myeloid Leukaemia

Question 8

What blood film findings are there in myelofibrosis?

Answer 8

Tear drop poiklocytes

Question 9

What is the definitive diagnosis of sickle cell?

Answer 9

Haemoglobin electrophoresis