05/02

Question 1

What is a thymoma commonly associated with?

Answer 1

Myasthenia Gravis- most common
SLE
Dermatomyositis

Is a tumour of the anterior mediastinum

Question 2

What is myelofibrosis?

Answer 2

Impairment of the bone marrow to produce normal blood cells

Leads to anaemia, splenomegaly and hypermetabolic syndrome e.g. weight loss and night sweats

Question 3

How is G6PD deficiency diagnosed?

Answer 3

G6PD enzyme assay completed at presentation and 3 months later to avoid false negatives

Question 4

What is the anti-coagulant of choice in patients with renal impairment?

Answer 4

Apixaban as it is not renally cleared

Question 5

What are signs of G6PD deficiency on blood films?

Answer 5

Heinz bodies

Bite and blister cells

Question 6

What features prompt an urgent FBC (within 48hrs) in people aged 0-24?

Answer 6

Pallor
Persistent fatigue
Unexplained fever
Unexplained persistent infections
Generalised lymphadenopathy
Persistent or unexplained bone pain
Unexplained bruising
Unexplained bleeding

Question 7

What are signs of transfusion associated lung injury?

Answer 7

Hypoxia
Pulmonary infiltrates on CXR
Fever
Hypotension

Question 8

What are signs of transfusion associated circulatory overload?

Answer 8

Pulmonary oedema
HTN

Not Hypotension!

Question 9

What is sideroblastic anaemia?

Answer 9

Condition where red cells fail to form haem

Leads to iron deposits around the mitochondria that form a ring around the nucleus called a ring sideroblast

Question 10

What are causes of sideroblastic anaemia?

Answer 10

Myelodysplasia
Alcohol
Lead
Anti- TB medications