10/03 Flashcards
What are features of non haemolytic febrile reaction?
Mild Fever
Chills
Slow or stop transfusion, give paracetamol and monitor
What are features of minor transfusion allergic reaction?
Urticaria
Pruritis
Temporarily stop transfusion
Anti histamines
Monitor
What are features of transfusion anaphylaxis?
Wheezing
Angiooedema
Hypotension
Stop transfusion
Give IM adrenaline
A-E
What are features of acute haemolytic reaction?
Abdo pain
Fever
Hypotension
Stop transfusion
Fluid resus
Check blood product and send for coombs test
What are features of transfusion associated circulatory overload?
Pulmonary oedema
HTN
Stop or slow transfusion
IV diuretic
What are features of transfusion related acute lung injury?
Hypoxia
Pulmonary infiltrates on CXR
Hypotension
Fever
Stop transfusion
Supportive care
What are features of hereditary spherocytosis?
FTT Jaundice Gallstones Splenomegaly Aplastic crises (parvovirus infection)
What investigations are needed for hereditary spherocytosis?
If diagnosis uncertain then EMA binding test
What is the management of polycythaemia rubra vera?
Aspirin to prevent clotting
Venesection to keep Hb in normal range
When is platelet transfusion indicated?
Platelet count <30 and clinically significant bleeding
What are investigation findings of multiple myeloma?
Bence Jones protein in urine
Monoclonal proteins in serum
Pepperpot skull on XR
Increased plasma cells in bone marrow
What is the pattern of inheritance of sickle cell disease?
Autosomal recessive
How is sickle cell definitively diagnosed?
Hb electrophoresis
