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Harr Heme/Coag/UA > 1.7 Lymphoproliferative and Myeloproliferative Disorders > Flashcards

1.7 Lymphoproliferative and Myeloproliferative Disorders Flashcards

1
Q

Repeated phlebotomy in patients with PV may lead to the development of:

A

IDA

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2
Q

In ET, the PLTs are:

A

Increased in number and functionally abnormal

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3
Q

Which of the following cells is considered pathognomonic for Hodgkin disease?

A

Reed–Sternberg (RS) cells

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4
Q

In myelofibrosis, the characteristic abnormal RBC morphology is that of:

A

Teardrop-shaped cells

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5
Q

PV is characterized by:

A

Absolute increase in total RBC mass

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6
Q

Features of secondary polycythemia include all of the following except:

A. Splenomegaly
B. Decreased O2 saturation
C. Increased RBC mass
D. Increased erythropoietin

A

Splenomegaly

(splenomegaly is in PV NOT Secondary PV)

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7
Q

Erythrocytosis in relative polycythemia occurs because of:

A

Decreased plasma volume of circulating blood

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8
Q

In PV, what is characteristically seen in peripheral blood?

A

Pancytosis

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9
Q

Leukocyte alkaline phosphatase (LAP) staining performed on a patient gives the
following results:

10 (0)
48 (1+)
38 (2+)
3 (3+)
1 (4+)

Calculate the LAP score.

A

137

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10
Q

CML is distinguished from leukemoid reaction by which of the following?

A. CML: low LAP; leukemoid: high LAP
B. CML: high LAP; leukemoid: low LAP
C. CML: high WBC; leukemoid: normal WBC
D. CML: high WBC; leukemoid: higher WBC

A

CML: low LAP; leukemoid: high LAP

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11
Q

Which of the following occurs in idiopathic myelofibrosis (IMF)?

A. Myeloid metaplasia
B. Leukoerythroblastosis
C. Fibrosis of bone marrow
D. All of these options

A

All of these options

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12
Q

What influence does the Philadelphia (Ph1) chromosome have on the prognosis of patients with CML?

A

The prognosis is better if Ph1 is present

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13
Q

Which of the following is (are) commonly found in CML?

A

An increase in basophils

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14
Q

In which of the following conditions does LAP show the least activity?

A. Leukemoid reactions
B. IMF
C. PV
D. CML

A

CML

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15
Q

A striking feature of the peripheral blood of a patient with CML is:

A

Presence of granulocytes at different stages of development

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16
Q

Which of the following is often associated with CML but not with AML?

A. Infections
B. WBCs greater than 20.0 × 109/L
C. Hemorrhage
D. Splenomegaly

A

Splenomegaly

17
Q

Multiple myeloma and Waldenström macroglobulinemia have all of the following in common except:

A. Monoclonal gammopathy
B. Hyperviscosity of blood
C. Bence–Jones protein in urine
D. Osteolytic lesions

A

Osteolytic lesions

18
Q

What is the characteristic finding seen in the peripheral blood smear from a patient with multiple myeloma?

A

Rouleaux

19
Q

All of the following are associated with the diagnosis of multiple myeloma except:

A. Marrow plasmacytosis
B. Lytic bone lesions
C. Serum and/or urine M component (monoclonal protein)
D. Ph1 chromosome

A

Ph1 chromosome

20
Q

Multiple myeloma is most difficult to distinguish from:

A

Benign monoclonal gammopathy

21
Q

The pathology of multiple myeloma includes which of the following?

A. Expanding plasma cell mass
B. Overproduction of monoclonal immunoglobulins
C. Production of osteoclast activating factor (OAF) and other cytokines
D. All of these options

A

All of these options

22
Q

Waldenström macroglobulinemia is a malignancy of the:

A

Lymphoplasmacytoid cells

23
Q

Cells that exhibit positive staining with acid phosphatase and are not inhibited by tartaric acid are characteristically seen in:

A

Hairy cell leukemia (HCL)

24
Q

The JAK2(V617F) mutation may be positive in all of the following chronic myeloproliferative disorders except:

A. ET
B. IMF
C. PV
D. CML

A

CML

25
Q

All of the following are major criteria for the 2008 WHO diagnostic criteria for ET except:

A. PLT count 450 × 109/L or greater
B. Megakaryocyte proliferation with large and mature morphology and no or little
granulocyte or erythroid proliferation
C. Demonstration of JAK2(V617F) or other clonal marker
D. Evidence of clonality

A

Evidence of clonality

Harr Heme/Coag/UA (18 decks)

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