1.7 Lymphoproliferative and Myeloproliferative Disorders Flashcards
Repeated phlebotomy in patients with PV may lead to the development of:
IDA
In ET, the PLTs are:
Increased in number and functionally abnormal
Which of the following cells is considered pathognomonic for Hodgkin disease?
Reed–Sternberg (RS) cells
In myelofibrosis, the characteristic abnormal RBC morphology is that of:
Teardrop-shaped cells
PV is characterized by:
Absolute increase in total RBC mass
Features of secondary polycythemia include all of the following except:
A. Splenomegaly
B. Decreased O2 saturation
C. Increased RBC mass
D. Increased erythropoietin
Splenomegaly
(splenomegaly is in PV NOT Secondary PV)
Erythrocytosis in relative polycythemia occurs because of:
Decreased plasma volume of circulating blood
In PV, what is characteristically seen in peripheral blood?
Pancytosis
Leukocyte alkaline phosphatase (LAP) staining performed on a patient gives the
following results:
10 (0)
48 (1+)
38 (2+)
3 (3+)
1 (4+)
Calculate the LAP score.
137
CML is distinguished from leukemoid reaction by which of the following?
A. CML: low LAP; leukemoid: high LAP
B. CML: high LAP; leukemoid: low LAP
C. CML: high WBC; leukemoid: normal WBC
D. CML: high WBC; leukemoid: higher WBC
CML: low LAP; leukemoid: high LAP
Which of the following occurs in idiopathic myelofibrosis (IMF)?
A. Myeloid metaplasia
B. Leukoerythroblastosis
C. Fibrosis of bone marrow
D. All of these options
All of these options
What influence does the Philadelphia (Ph1) chromosome have on the prognosis of patients with CML?
The prognosis is better if Ph1 is present
Which of the following is (are) commonly found in CML?
An increase in basophils
In which of the following conditions does LAP show the least activity?
A. Leukemoid reactions
B. IMF
C. PV
D. CML
CML
A striking feature of the peripheral blood of a patient with CML is:
Presence of granulocytes at different stages of development
Which of the following is often associated with CML but not with AML?
A. Infections
B. WBCs greater than 20.0 × 109/L
C. Hemorrhage
D. Splenomegaly
Splenomegaly
Multiple myeloma and Waldenström macroglobulinemia have all of the following in common except:
A. Monoclonal gammopathy
B. Hyperviscosity of blood
C. Bence–Jones protein in urine
D. Osteolytic lesions
Osteolytic lesions
What is the characteristic finding seen in the peripheral blood smear from a patient with multiple myeloma?
Rouleaux
All of the following are associated with the diagnosis of multiple myeloma except:
A. Marrow plasmacytosis
B. Lytic bone lesions
C. Serum and/or urine M component (monoclonal protein)
D. Ph1 chromosome
Ph1 chromosome
Multiple myeloma is most difficult to distinguish from:
Benign monoclonal gammopathy
The pathology of multiple myeloma includes which of the following?
A. Expanding plasma cell mass
B. Overproduction of monoclonal immunoglobulins
C. Production of osteoclast activating factor (OAF) and other cytokines
D. All of these options
All of these options
Waldenström macroglobulinemia is a malignancy of the:
Lymphoplasmacytoid cells
Cells that exhibit positive staining with acid phosphatase and are not inhibited by tartaric acid are characteristically seen in:
Hairy cell leukemia (HCL)
The JAK2(V617F) mutation may be positive in all of the following chronic myeloproliferative disorders except:
A. ET
B. IMF
C. PV
D. CML
CML
All of the following are major criteria for the 2008 WHO diagnostic criteria for ET except:
A. PLT count 450 × 109/L or greater
B. Megakaryocyte proliferation with large and mature morphology and no or little
granulocyte or erythroid proliferation
C. Demonstration of JAK2(V617F) or other clonal marker
D. Evidence of clonality
Evidence of clonality
