1.2 Normocytic and Normochromic Anemias Flashcards
Hypersplenism is characterized by:
Leukopenia
Which of the following organs is responsible for the “pitting process” in RBCs?
A. Liver
B. Spleen
C. Kidney
D. Lymph nodes
Spleen
Spherocytes differ from normal RBCs in all of the following except:
A. Decreased surface to volume
B. No central pallor
C. Decreased resistance to hypotonic saline
D. Increased deformability
Increased deformability
Which of the following is not associated with HS?
A. Increased osmotic fragility
B. MCHC greater than 36%
C. Intravascular hemolysis
D. Extravascular hemolysis
Intravascular hemolysis
Which of the following disorders has an increase in osmotic fragility?
A. Iron deficiency anemia (IDA)
B. Hereditary elliptocytosis (HE)
C. Hereditary stomatocytosis
D. Hereditary spherocytosis (HS)
Hereditary spherocytosis (HS)
The anemia seen in sickle cell disease is usually:
Normocytic, normochromic
Which is the major Hgb found in the RBCs of patients with the sickle cell trait?
Hgb A
Select the amino acid substitution that is responsible for sickle cell anemia.
Valine is substituted for glutamic acid at the sixth position of the β-chain
All of the following are usually found in Hgb C disease except:
A. Hgb C crystals
B. Target cells
C. Lysine substituted for glutamic acid at the sixth position of the β–chain
D. Fast mobility of Hgb C at pH 8.6
Fast mobility of Hgb C at pH 8.6
Which of the following Hgbs migrates to the same position as Hgb A2 at pH 8.6?
Hgb C
Which of the following electrophoretic results is consistent with a diagnosis of the sickle cell trait?
A. Hgb A: 40% Hgb S: 35% Hgb F: 5%
B. Hgb A: 60% Hgb S: 40% Hgb A2: 2%
C. Hgb A: 0% Hgb A2: 5% Hgb F: 95%
D. Hgb A: 80% Hgb S: 10% Hgb A2: 10%
B. Hgb A: 60% Hgb S: 40% Hgb A2: 2%
In which of the following conditions will autosplenectomy most likely occur?
Sickle cell disease
Which of the following is most true of paroxysmal nocturnal hemoglobinuria (PNH)?
It is a rare acquired stem cell disorder that results in hemolysis
Hemolytic uremic syndrome (HUS) is characterized by all of the following except:
A. Hemorrhage
B. Thrombocytopenia
C. Hemoglobinuria
D. Reticulocytopenia
Reticulocytopenia
The autohemolysis test result is positive in all of the following conditions except:
A. Glucose-6-phosphate dehydrogenase (G6PD) deficiency
B. HS
C. Pyruvate kinase (PK) deficiency
D. PNH
PNH
Which antibody is associated with paroxysmal cold hemoglobinuria (PCH)?
Anti-P
All of the following are associated with intravascular hemolysis except:
A. Methemoglobinemia
B. Hemoglobinuria
C. Hemoglobinemia
D. Decreased haptoglobin
Methemoglobinemia
Autoimmune hemolytic anemia (AIHA) is best characterized by which of the following?
Spherocytic RBCs
“Bite cells” are usually seen in patients with:
G6PD deficiency
The morphological classification of anemias is based on which of the following?
RBC indices
Which of the following is a common finding in aplastic anemia?
Peripheral blood pancytopenia
Congenital dyserythropoietic anemias (CDAs) are characterized by:
Bizarre multinucleated erythroblasts
Microangiopathic hemolytic anemia is characterized by:
Schistocytes and NRBCs
Which antibiotic(s) is (are) most often implicated in the development of aplastic anemia?
Chloramphenicol
Sickle cell disorders are:
Hereditary, intracorpuscular RBC defects
Which of the following conditions may produce spherocytes in a peripheral blood smear?
A. Pelger–Huët anomaly
B. Pernicious anemia
C. AIHA
D. Sideroblastic anemia
AIHA
A patient’s peripheral blood smear reveals numerous NRBCs, marked variation of RBC morphology, and pronounced polychromasia. In addition to decreased Hgb and decreased Hct values, what other CBC parameters may be anticipated
Increased MCV
What RBC inclusion may be seen in the peripheral blood smear from a patient postsplenectomy?
Howell–Jolly bodies
Reticulocytosis usually indicates:
RBC regeneration
Hereditary pyropoikilocytosis (HP) is an RBC membrane defect characterized by:
Misshapen budding fragmented cells
