Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Harr Heme/Coag/UA > 1.2 Normocytic and Normochromic Anemias > Flashcards

1.2 Normocytic and Normochromic Anemias Flashcards

1
Q

Hypersplenism is characterized by:

A

Leukopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which of the following organs is responsible for the “pitting process” in RBCs?

A. Liver
B. Spleen
C. Kidney
D. Lymph nodes

A

Spleen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Spherocytes differ from normal RBCs in all of the following except:

A. Decreased surface to volume
B. No central pallor
C. Decreased resistance to hypotonic saline
D. Increased deformability

A

Increased deformability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which of the following is not associated with HS?

A. Increased osmotic fragility
B. MCHC greater than 36%
C. Intravascular hemolysis
D. Extravascular hemolysis

A

Intravascular hemolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which of the following disorders has an increase in osmotic fragility?

A. Iron deficiency anemia (IDA)
B. Hereditary elliptocytosis (HE)
C. Hereditary stomatocytosis
D. Hereditary spherocytosis (HS)

A

Hereditary spherocytosis (HS)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

The anemia seen in sickle cell disease is usually:

A

Normocytic, normochromic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which is the major Hgb found in the RBCs of patients with the sickle cell trait?

A

Hgb A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Select the amino acid substitution that is responsible for sickle cell anemia.

A

Valine is substituted for glutamic acid at the sixth position of the β-chain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

All of the following are usually found in Hgb C disease except:

A. Hgb C crystals
B. Target cells
C. Lysine substituted for glutamic acid at the sixth position of the β–chain
D. Fast mobility of Hgb C at pH 8.6

A

Fast mobility of Hgb C at pH 8.6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Which of the following Hgbs migrates to the same position as Hgb A2 at pH 8.6?

A

Hgb C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Which of the following electrophoretic results is consistent with a diagnosis of the sickle cell trait?

A. Hgb A: 40% Hgb S: 35% Hgb F: 5%

B. Hgb A: 60% Hgb S: 40% Hgb A2: 2%

C. Hgb A: 0% Hgb A2: 5% Hgb F: 95%

D. Hgb A: 80% Hgb S: 10% Hgb A2: 10%

A

B. Hgb A: 60% Hgb S: 40% Hgb A2: 2%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

In which of the following conditions will autosplenectomy most likely occur?

A

Sickle cell disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which of the following is most true of paroxysmal nocturnal hemoglobinuria (PNH)?

A

It is a rare acquired stem cell disorder that results in hemolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Hemolytic uremic syndrome (HUS) is characterized by all of the following except:

A. Hemorrhage
B. Thrombocytopenia
C. Hemoglobinuria
D. Reticulocytopenia

A

Reticulocytopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

The autohemolysis test result is positive in all of the following conditions except:

A. Glucose-6-phosphate dehydrogenase (G6PD) deficiency
B. HS
C. Pyruvate kinase (PK) deficiency
D. PNH

A

PNH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which antibody is associated with paroxysmal cold hemoglobinuria (PCH)?

A

Anti-P

17
Q

All of the following are associated with intravascular hemolysis except:

A. Methemoglobinemia
B. Hemoglobinuria
C. Hemoglobinemia
D. Decreased haptoglobin

A

Methemoglobinemia

18
Q

Autoimmune hemolytic anemia (AIHA) is best characterized by which of the following?

A

Spherocytic RBCs

19
Q

“Bite cells” are usually seen in patients with:

A

G6PD deficiency

20
Q

The morphological classification of anemias is based on which of the following?

A

RBC indices

21
Q

Which of the following is a common finding in aplastic anemia?

A

Peripheral blood pancytopenia

22
Q

Congenital dyserythropoietic anemias (CDAs) are characterized by:

A

Bizarre multinucleated erythroblasts

23
Q

Microangiopathic hemolytic anemia is characterized by:

A

Schistocytes and NRBCs

24
Q

Which antibiotic(s) is (are) most often implicated in the development of aplastic anemia?

A

Chloramphenicol

25
Q

Sickle cell disorders are:

A

Hereditary, intracorpuscular RBC defects

26
Q

Which of the following conditions may produce spherocytes in a peripheral blood smear?

A. Pelger–Huët anomaly
B. Pernicious anemia
C. AIHA
D. Sideroblastic anemia

A

AIHA

27
Q

A patient’s peripheral blood smear reveals numerous NRBCs, marked variation of RBC morphology, and pronounced polychromasia. In addition to decreased Hgb and decreased Hct values, what other CBC parameters may be anticipated

A

Increased MCV

28
Q

What RBC inclusion may be seen in the peripheral blood smear from a patient postsplenectomy?

A

Howell–Jolly bodies

29
Q

Reticulocytosis usually indicates:

A

RBC regeneration

30
Q

Hereditary pyropoikilocytosis (HP) is an RBC membrane defect characterized by:

A

Misshapen budding fragmented cells

Harr Heme/Coag/UA (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions