1.3 Hypochromic and Microcytic Anemias

Question 1

The osmotic fragility test result in a patient with thalassemia major would most likely show:

Answer 1

Decreased hemolysis

Question 2

All of the following are characteristic findings in a patient with IDA except:

A. Microcytic, hypochromic RBC morphology
B. Decreased serum iron and ferritin levels
C. Decreased total iron-binding capacity (TIBC)
D. Increased RBC protoporphyrin

Answer 2

Decreased total iron-binding capacity (TIBC)

Question 3

IDA may be distinguished from anemia of chronic infection by:

Answer 3

TIBC

Question 4

Which anemia has RBC morphology similar to that seen in IDA?

Answer 4

Thalassemia syndrome

Question 5

IDA is characterized by:

Answer 5

Decreased plasma iron, decreased % saturation, increased TIBC

Question 6

Storage iron is usually best determined by:

Answer 6

Serum ferritin levels

Question 7

All of the following are associated with sideroblastic anemia except:

A. Increased serum iron
B. Ringed sideroblasts
C. Hypochromic anemia
D. Decreased serum ferritin

Answer 7

Decreased serum ferritin

Question 8

What is the basic hematological defect seen in patients with thalassemia major?

Answer 8

β-chain synthesis

Question 9

Which of the following is the primary Hgb in patients with thalassemia major?

Answer 9

Hgb F

Question 10

A patient has an Hct of 30%, an Hgb of 8 g/dL, and a RBC count of 4.0 × 10^12/L. What is the morphological classification of this anemia?

Answer 10

Microcytic, hypochromic

Question 11

In which of the following conditions is Hgb A2 elevated?

A. Hgb H
B. Hgb SC disease
C. β-thalassemia minor
D. Hgb S trait

Answer 11

β-thalassemia minor

Question 12

Which of the following parameters may be similar for the anemia of inflammation and IDA?

A. Normocytic indices
B. Decreased serum iron concentration
C. Ringed sideroblasts
D. Pappenheimer bodies

Answer 12

Decreased serum iron concentration