1.4 Macrocytic and Normochromic Anemias Flashcards
Which morphological classification is characteristic of megaloblastic anemia?
Macrocytic, normochromic
Which anemia is characterized by lack of intrinsic factor that prevents B12 absorption?
Pernicious anemia
All of the following are characteristics of megaloblastic anemia except:
A. Pancytopenia
B. Elevated reticulocyte count
C. Hypersegmented neutrophils
D. Macrocytic erythrocyte indices
Elevated reticulocyte count
A patient with a vitamin B12 anemia is prescribed a high dosage of folate. Which of the following is expected as a result of this treatment?
An improvement in hematological abnormalities
Which of the following disorders is associated with ineffective erythropoiesis?
Megaloblastic anemia
A 50-year-old patient is suffering from pernicious anemia. Which of the following laboratory data are most likely for this patient?
A. RBC = 2.5 × 1012/L; WBC = 12,500/µL (12.5 × 109/L); PLT = 250,000/µL (250 × 109/L)
B. RBC = 4.5 × 1012/L; WBC = 6,500/µL (6.5 × 109/L); PLT = 150,000/µL (150 × 109/L)
C. RBC = 3.0 × 1012/L; WBC = 5,000/μL (5.0 × 109/L); PLT = 750,000/µL (750 × 109/L)
D. RBC = 2.5 × 1012/L; WBC = 2,500/µL (2.5 × 109/L); PLT = 50,000/µL (50 × 109/L)
D. RBC = 2.5 × 10^12/L; WBC = 2,500/µL (2.5 × 10^9/L); PLT = 50,000/µL (50 × 10^9/L)
Which of the following may be seen in the peripheral blood smear from a patient with obstructive liver disease?
Macrocytes
The macrocytes typically seen in megaloblastic processes are:
Oval shaped
Which of the following are most characteristic of the RBC indices associated with megaloblastic anemias?
A. MCV 99 fL, MCH 28 pg, MCHC 31%
B. MCV 62 fL, MCH 27 pg, MCHC 30%
C. MCV 125 fL, MCH 36 pg, MCHC 34%
D. MCV 78 fL, MCH 23 pg, MCHC 30%
C. MCV 125 fL, MCH 36 pg, MCHC 34%
A patient has 80 NRBCs per 100 leukocytes. In addition to increased polychromasia on the peripheral blood smear, what other finding may be present on the CBC?
Increased MCV
