160 warfarin

Question 1

Therapeutic classification

Answer 1

anticoagulant

Question 2

Pharmacologic classification

Answer 2

Vitamin K antagonist

Question 3

Mechanism of action

Answer 3

Inhibits two enzymes involved in formation of activated vitamin K, inhibits synthesis of new clotting factors

Question 4

indications

Answer 4

Prophylaxis arterial thomboembolism, DVT, pulmonary embolism, long-term indwelling catheters

Question 5

precautions

Answer 5

dental procedures, CHF

Question 6

contraindications

Answer 6

recent trauma, active internal bleeding, serious bleeding disorders, intracranial hemmorrhage, severe Hypertension, bacterial endocarditis, hepatic and renal impiarment, pregnancy

Question 7

drug interactions

Answer 7

See table 41.4, other anticoagulants, barbituates, corticosteroids, ginseng, ginkgo, green tea, cranberry, feverfew, vitamin E, vitamin K

Question 8

pregnancy category

Answer 8

X

Question 9

adverse effects

Answer 9

Microembolism, osteoporosis, bone Fx, abnormal bleeding

Question 10

nursing considerations

Answer 10

heath Hx; moniter PT/INR; moniter urine, stool, liver, blood; moniter risk groups for non-adherence

Question 11

teaching

Answer 11

avoid accident prone activities, report bleeding, stop and report hepatitis, use consistently, avoid high-fat diet, avoid excessive alcohol, inform dentist, avoid pregnancy, avoid changes in levels of vitamin K foods

Question 12

Antidote

Answer 12

vinamin K

Question 13

common route

Answer 13

oral