160 clopidogrel (plavix)

Question 1

Therapeutic classification

Answer 1

Antiplatelet agent

Question 2

Pharmacologic classification

Answer 2

ADP receptor blocker

Question 3

Mechanism of action

Answer 3

Inhibits ADP receptors on platelets and prolongs bleeding time by irreversibly inhibiting platelet aggregation

Question 4

indications

Answer 4

reduce risk of CVA/MI, reduce thrombolytic events post-CVA/MI, prevent DVT, prevent thrombi formation

Question 5

precautions

Answer 5

high risk of bleeding, severe hepatic disease

Question 6

contraindications

Answer 6

active bleeding

Question 7

drug interactions

Answer 7

increased risk of bleeding with anticoagulants, antiplatelets thrombolytic agents and NSAIDs; diminished antiplatelet actioins with drugs that inhibit hepatic metabolic enzymes; increased anticoagulant activity with drugs that increase hepatic metabolic enzymes

Question 8

pregnancy category

Answer 8

B

Question 9

adverse effects

Answer 9

flu-like syndrome, headache, diarrhea, dizziness, bruising, URTI (upper resp. tract infeciton), rash, puriti, serious effect: abnormal bleeding

Question 10

nursing considerations

Answer 10

assess current use of anticoagulants and NSAIDs, assess for increased bleeding risk, moniter for bleeding, evaluate unexpained fever/infection

Question 11

teaching

Answer 11

immediately report bleeding, know it may take longer to stop bleeding, do not stop taking drug, do not use NSAIDs or OTC meds or supplements, inform dentist

Question 12

Antidote

Answer 12

irreversible action

Question 13

common route

Answer 13

PO