14 - Pharm of Obstructive Dz

Question 1

PSNS receptor that causes bronchoconstriction

Answer 1

M3

Question 2

3 categories of bronchodilators

Answer 2

beta 2 agonists
anticholinergics
methylxanthines

Question 3

short vs long acting beta 2 agonist names

Answer 3

short - albuterol, pirbuterol, bitolterol

long - salmeterol, formoterol, indacaterol

Question 4

short vs long acting anticholinergic for obstructive dz examples

Answer 4

short - ipratropium

long - tiotropium

Question 5

theophylline tox

Answer 5

GI sx most common, CNS stimulation, tachycardia

Question 6

response to diff bronchodilators in asthma vs COPD

Answer 6

SABA - asthma develops tolerance, use only for rescue
COPD no tolerance, regularly dosed

LABA - asthma dont use as monotherapy
COPD good for monotherapy

anticholinergic - asthma good for acute
COPD good for acute and stable dz

Question 7

zileuton

Answer 7

5-LO synthesis inhibitor
significant drug interactions w/ other meds metab in liver
reduces leukotriene effects

Question 8

zafirlukast and montelukast

Answer 8

leukotriene receptor antagonists

longer acting than zileuton

Question 9

leukotriene modifiers can uncover what other dz in asthma pts?

Answer 9

Churg Strauss

Question 10

which is better to add to ICS in asthma - LABA or anti leukotrienes?

Answer 10

LABA

Question 11

cromolyn sodium is most effective in which patients

Answer 11

atopic patients

Question 12

roflumilast

Answer 12

pde4 inhib sometimes used in severe COPD