1.4 Flashcards
2 plasma membrane folds
lateral, basal
Extracellular adhesion
cohesion (transmembrane glycoproteins)
intercellular jxns (3)
Zonula occludens (tight) Zonula adherins (int) Macula adherens (desmosome)
Tight junction
close to apical surface
belt-like
prevents passage of materials
intermediate jxns
belt-like
no membrane fusion
desmosome
disc-shaped
no membrane fusion
tonofilaments inserting
firm adhesion of ADJACENT cells
which proteins associate with tight junctions?
ZO1, ZO2, ZO3
which cells have abundant desmosomes?
epithelial and cardiac
Gap jxns
disc shaped
no membrane fusion
contains CONNEXONS
allows cell-cell communication
which cells have gap junctions?
epithelia, muscle, fibroblasts
junctional complex has what 3 things?
ZO, ZA, MA
Hemidesmosome
CELL-ECM
- dif proteins than desmosome
- tonofilaments
Basal lamina
extracellular product of epithelial cells
what is basal lamina made of?
type 4 collagen, laminin, entactin, heparan sulfate
reticular lamina
deeper, more solid; has anchoring fibrils
fxn of basal lamina (8)
support for cells, filtration/diffusion, cell-cell int, polarity, regulate proliferation and differentation, influence metabolism, protein organization, cell migration pathways
Epithelia does NOT have _______ but DOES have ______-
blood vessels, nerves
basement membrane is made up of what
basal lamina, reticular lamina