13.5 Ovary Flashcards

1
Q

what is the funcitonal unit of the ovary

A

follicle

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2
Q

what 3 cells are in the follice from center to outside

A

follicle in center, Granulosa cells outside that , Theca cells on outside

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3
Q

theca cells respond to what homo to produce what?

A

LH stimulates theca cells to produce Androgen

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4
Q

What hormone are grnaulosa cells stimulated by

A

FSH

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5
Q

what do granuloma cells convert (from what in to what)

A

they convert Androgen produced by theca cells into estradiol

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6
Q

what does estradiol do at normal levels in the ovary

A

drives proliferative phase of endometrial cycle

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7
Q

at very high levels, what does estradiol surge accomplish

A

it paradoxically feeds back to increase LH production –> LH surge

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8
Q

What does the LH surge accomplish? Marking what phase beginning

A

it leads to ovulation marking the beginning of the secretory phase

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9
Q

what happens to the follicle after ovulation

A

it becomes the corpus luteum

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10
Q

What does the corpus luteum secrete and why

A

it secretes progesterone to maintain the secretory phase (preparing the endometrium for pregnancy)

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11
Q

a hemorrhagic luteal cyst occurs when and how?

A

hemorrhage into the corpus lutem during early pregnancy usually

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12
Q

what causes follicular cysts?

A

degeneration of follicles

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13
Q

define polycystic ovarian disease

A

multiple ovarian follicular cysts dt homo imbalance

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14
Q

What specific hormone ratio is found in PCOD

A

LH:FSH >2

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15
Q

in PCOD what is the classic pt (4)

A
(female duh)
obese
infertile
oligomennorhea
hirsutism
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16
Q

what cuases hirsutism in PCOD pt

A

high LH induces Androgen production in theca cells

17
Q

What causes higher risk for endometrial carcinoma in PCOD

A

high LH –> Androgen production by theca cells –> conversion of androgen to estrone by adipose tissue–> high levels of estrone increase risk of endometrial carcinoma

18
Q

What causes degeneration of follicles (follicular cysts) in PCOD

A

high LH –> Androgen production by theca cells –> conversion of androgen to estrone by adipose tissue–> high levels of estrone feedback inhibits FSH production–> cystic degeneration of follicles

19
Q

what disease will PCOD develop 10-15 years later?

A

T2DM dt insulin resistance