13.3 Cervix Flashcards
What type of cell is located in the endocervix (3 words)
Simple Columnar epithelium
What type of cell is located in the exocervix (3 words)
non-keratinized stratified Squamous
Where does HPV preferentiially infect
the transformation zone
What normally happens to HPV infx
immune system clears it
What happens in persistent HPV infx
increased risk for cervical dysplasia
What is another name for cervical dysplasia
Cervial intraepithelial Neoplasia
What are the low risk HPV types and what do they cuase
6, 11 cause condylomas of lower reproductive tract
What are the high risk HPV types and what do they cuase
16, 18, 31, 33
they cause carcinomas
What 2 proteins do high risk HPV strains produceq
E6, E7
What does E6 do that makes them high risk
E6 knocks out p53 (a tumor suppressor gene)
What does E7 do that makes them high risk
E7 knocks out Rb (a tumor suppressor gene)
What does p53 do in the cell to prevent uncontrolled growth
it induces p21 to inaCTIVATE CDKs–> hypophosphorylation (and activation) of Rb
What does Rb do to prevent uncontrolled cell growth
Rb normally binds (thus inactivating) E2F ( a transription factor that prevents the progression to G1/S phase
what 4 things chcize CIN
- koilocytic change
- disordered cellular maturation
- nuclear atypia
- increased mitosis
What criteria decides CIN staging?
the amount (thickness) of epithelial involvment by dysplastic cells
CIN I, II, III involve how much of thickness of epithelium of cervix each?
I = 1/3 II = 2/3 III = almost all
What does CIN III progress to?
Carcinoma in Situ
How is carcinoma in situ defined
full thickness of epithelium is dysplastic
what differentiates dysplasia from carcinoma ?
Reversibility!!!
What does Carcinoma In Situ progress to?
Invasive SqCC
Does all CIN progres always? Why or why not?
No, lower stage usually regresses, CIN III usually progresses
What defines invasive carcinoma
invades BM
define cervical carcinoma
invasive carcinoma of cervical epithelium
what is MC age for cervical carcinoma and why
40-50 yo bc women usually get HPV in 20s and it takes 20-30 yrs to develop cervical carcinoma
