13.5 Effects of Gonadal Hormones on Adults Flashcards

1
Q

what clearly demonstrates he role of gonadal hormones in male sexual behaviour

A

orchidectomy

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2
Q

what are the two main conclusions from the Bremer study on orchidectomized males?

A
  1. reduces sexual interest and behaviour

2. rate and degree of loss are variable

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3
Q

what are the main outcomes of orchidectomy on sexual behaviours (4)

A
  • about half of cases will become asexual within a few weeks
  • others can lose their ability to get hard but still have sexual interest and pleasure
  • some can still cpulate, but less enthusiastically
  • body changes included reduction of body hair on torso, limbs, face, deposition of fat on hips and chest, softening of the skin, reduced muscle mass
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4
Q

how many out of the 102 orchidectomized sex offenders reengaged in sex crimes?

A

3

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5
Q

why do some males remain sexually active following orchidectomy?

A

adrenal androgens may play some role - non direct evidence for this tho

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6
Q

what confirms the assumption that the main effects of orchidectomy are associated with the loss of T?

A

replacement injections of T

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7
Q

describe the case of the man who lost and regained his manhood

A

castrated in war, soft body w little muscle, wider hips and narrower shoulders, impotent
- T injections
- after 5, and rapid and prolonged erections
after 12 weeks, gained 18 pounds of muscle
- didn’t eliminate his sterility

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8
Q

what are the two widespread assumptions that follow from the necessity of T in male sexual behaviours
are they correct?

A
  1. level of a mans sexuality is related to his T levels in blood
  2. mans sex drive can be increased by increasing levels of T
    - NOPE, unrelated in both cases
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9
Q

explain the Grunt and Young experiments on sexual behaviour inn response to T

A
  • rated sexual behaviour of the male guinea pigs in the study
  • based on the ratings, grouped them into low, medium, high
  • castration, all sex drives fell to negligible within weeks
  • recovered after initiation of T replacement
  • even tho they all received the same amount, they returned to their old level of sexuality
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10
Q

what is Dihydrotestosterone and why is it interesting

A
  • non aromatizable androgenn
  • restores copulatory behaviour in castrated male primates, not in rodents
  • indicates that restoration of copulatory behaviour by T has different mechanisms in rodents and primates
  • directly due to T in primates
  • due to aromatized estradiol in rodents
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11
Q

How long are the gonadal hormone cycles of mature female rats and guinea pigs
describe

A

4 days

  • gradual increase ion estrogen secretion by developing follicles in the 2 days before ovulation
  • sudden surge in progesterone as the egg is release
  • initiate estrus (12-18 hours when the female is fertile, receptive, proceptive and sexually attractive
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12
Q

what does the close relation between the hormone cycle and estrous cycle indicate about sexual behaviour in female rats and guinea pigs

A

under the control of hormonal control since sex behaviours match up so well with gonadal hormones

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13
Q

Do the effects of ovariectomy confirm or refute the position that female rodent estrus cycles are determined by gonadal hormone cycles?
- How? (2)

A

confirms

  • ovariectomy produces decline in both receptive and proceptive behaviours
  • estrus can be induced in castrated females if you inject estradiol and then progesterone and day and a half later
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14
Q

how are female primates different from rodent and other mammals in terms of the hormonal control of their sexual behaviour?
is this a 100% thing?

A

only female mammals who are motivated to copulate during periods of non-fertility

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15
Q

what are the three findings that support the view that human primates are still effected by hormonal patterns>?

A
  1. more likely to engage in masturbation/ sex
  2. prefer male faces
  3. ovariectomy reduces sexual desire and frequency of sexual fantasies
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16
Q

What are the four relevant findings that question which ovarian hormone is responsible for female sexual desire?

A
  1. Roney and Simons - only high estradiol levels are related to human females sexual desire
  2. nonhuman female primates - replacement injections of T but not estradiol increased perceptivity of ovariwctomized, adrenalectomized female rhesus monkeys
  3. postmenopausal human females - estrogen therapy renews sexual interest sometimes, T therapy too sometimes
  4. T increases sex desire I post menopausal human females only in supraphysiological levels
17
Q

what are anabolic steroids

A

steroids such as T that have anabolic (growth promoting) effects

18
Q

is testosteron a useful anabolic?

A

nope, broken down soon after injection and has undesirable side effects

19
Q

have chemists been able to synthesize anabolics that take along time to be broken down and are without side effects?

A

nope, only the former is available

20
Q

what is the global lifetime prevalence rates for anabolic steroid use?

A

6.4% in males, 1.6% in females

21
Q

why do we not fully understand the risks of testosterone abuse?

A

Bc its illegal, there are more than 100 derivatives, and users vary greatly in doses and admin patterns, hazardous effects are well documented in only a small proportion of users

22
Q

wha are the main negative side effects of anabolic steroids on the internal organs?

A

cardiovascular effects can lead to death

oral anabolics can effect the liver and cause tumours

23
Q

what are some of the less dangerous but unfortunate side effects of anabolic steroid use?

A

muscle spasms and pains, blood in the urine, acne, general swelling from the retention of water, tongue bleeding, nausea, vomiting, fits of depression and anger

24
Q

Do large doses of anabolics increase sexual function in males (3)

A

No, can reduce gonadotropin release which

  1. reduces testicular activity causing testicular atrophy
  2. sterility
  3. Gynecomastia - breast growth in males
25
Q

why do we think anabolic users get gynecomastia

A

presumably bc of the aromatization of anabolics to estrogens

26
Q

what are the negative effects of anabolic abuse in females? (8)

A
  1. amenorrhea (cessation of menstruation)
  2. sterility
  3. hirsutism (growth of body hair)
  4. clitoral growth
  5. development of male body shape
  6. baldness
  7. breast shrinking
  8. deepening or coarsening of the voice
    - not always reversible
27
Q

what are the two mai points of concern about the adverse health consequences of anabolics

A
  1. use of anabolic during puberty is super risky

2. many adverse effects can take years to develop