13: Psychobiology Flashcards

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1
Q

What are the different types of stress?

A

Can be a stimulus E.g. events that place strong demands on us

Can be a response - physiological response to stress –> fight and flight (also negative emotions etc)

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2
Q

What happens during a stress response?

A

Normally SNS increase + activation of Hipoythalamic pituitary adrenocortical axis –> more sustained stress response

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3
Q

Explain the General Adaptation Syndrome to stress

A
  1. alarm reaction
    • shift to SNS reaction
    • caues increased arousal
  2. resistance
    • endocriene system activation
    • and activation of immune system
      • Maintains increased arousal
  3. exhaustion
    • depletion of resurces of endocrine (adrenals) and immune system –> more vulnerable to consequences of stress (chronic stress)
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4
Q

What is stress?

A

Stress is a combination of a stimulus and a resposnse –> Can be positive and negative

  • Togehter:
    • pattern of cognitive appraisals
    • emotional reactions
    • physiological responses
    • and behavioural tendencies
  • that occur in response to a perceived imbalance between
    • situational demands (primary appraisal) and
    • resources needed to cope with them (secondary appraisal).
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5
Q

What is a cognitive appraisal of stress?

A

Primary appraisal of stress

  1. How hard will it be?
  2. How much will it count?

Secondary appraisal

  • How does my current situation influence it? e.g.
    • what do i already know to pass the exam

Also taken into account:

  • consequences of failing
  • likelyhood and seriousness can be evaluated differently depending on personal beliefs
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6
Q

Explain the relationship between stress and performance

A

for good performance: a little bit of stress is good

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7
Q

What is the overall relationship between stress and disease

A

Stress might lead to

  1. unhealthy lifestyle choices (behavioral change)
  2. physiological changes due to stress

–> Increasing the likelyhood of Disease

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8
Q

Explain the relationship between CHD and stress

A

High response to stress: –> higher likelihood of coronary artery calcification

  • more stress might lead to increase in CHD
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9
Q

Explain the relationship between would healing and stress

A

Slower would healing in more stressful period - might be due to decreased production of IL1(decreased immune function)

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10
Q

What are the features of a Type A (personality)?

A
  • Ultra-competitice
  • Time urgency
  • Free-floating
  • hostility
  • Hyper-aggressiveness
  • Focus on accomplishment
  • Competitive and goal-driven
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11
Q

Explain the relationship between a Type A personality and CHD

A

Type A personalities have higher risk of CHD

  • (doubled) due to
    • also due to unhealthy lifestyle changes
    • but also just behavior pattern alone 30% increase in risk
  • Main driver; hostility and quickness to aggression for behavior factor
  • (but poor replication, not 100% proved)
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12
Q

Explain the relationship between depression and CHD

A

Depression: increased risk in CHD and outcome of someone with CHD poorer (increased mortality)

Possibly due to

  • phyiolgical changes (e.g. platelet activation)
  • and behavior changes (smoking)
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13
Q

What are different coping mechanisms with stress

A
  1. problem focussed
  2. emotion focussed
  3. Seeking social support
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14
Q

Explain the difference between approach and avoidance in coping with illness/ stress

A
  1. Approach = activity that is oriented toward a threat (e.g. problem-solving, planning a response)
  2. Avoidance = activity that is oriented away from a threat (e.g., denial, distraction) –> coping strategy might depend in the situation
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15
Q

What is the role of social support in health?

A

Important: people who rate social support higher

  • live longer possibly
  • increased quality of life
  • possibly: low social support leading to side effect like
    • poor health behavior,
    • depression etc

True mechanism is not clear

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16
Q

What is the placebo effect?

A

Placebo effect: expectation of response influences the outcome

17
Q

What is the nocebo effect?

A

Nocebo effect: expectation of negative effect that occurs after receiving treatment causes negative symptoms

18
Q

What are the psychological mechanisms that underly the placebo effect?

A
  1. framing –> e.g. explanation in post-operative pain
  2. social learning –> seeing positive results in someone you know from medication
  3. experiential – >you have experienced pain relief from tablets
  4. learning –> see : tablet helps: tablet that looks similar helps too classical conditioning
19
Q

What are the clinical implications of the placebo effect

A
  • E.g. dose extending in opioid use
  • but still early stage
20
Q

What is the problem with the clinical use of placebo

A

Ethical issues: Might damage patient-doctor relationship (lying) - but also open placebo works

21
Q

What are the different factors that influence the strenght towards a Placebo response?

What are the advantages?

A

influenced by

  • form (e.g. branded table) and
  • manner (positive framing)
  • Expecially helpful in conditions with psychological compnents (e.g. pain: has always a psychological/subjective compnent)
  • normally; no negative side effect (except of nocebo)
22
Q

Do Placebos still work even when saying they are placebos?

A

YES