1.3 Cerebrospinal fluid (Chemical Examination)

Question 1

Normal values for Total proteins? compare it to plasma serum?

Answer 1

15 - 45 mg/dL (1% of plasma serum TP)

Question 2

CSF protein electrophoresis:

Prealbumin, albumin

a. Protein fractions
b. oligoclonal bands

Answer 2

a

Question 3

CSF protein electrophoresis:

alpha-globulins transferrin, tau protein

a. Protein fractions
b. oligoclonal bands

Answer 3

a

Question 4

What protein is unique in CSF?

Answer 4

Tau protein

Question 5

A carbohydrate deficient variant of transferrin that may be used as landmark in identifying an unknown as CSF

Answer 5

Tau protein

Question 6

CSF protein electrophoresis:

Gamma globulins

a. Protein fractions
b. oligoclonal bands

Answer 6

a

Question 7

CSF protein electrophoresis:

Located in gamma regions

a. Protein fractions
b. oligoclonal bands

Answer 7

b

Question 8

What proteins are not present in significant amount of protein in CSF but significant in plasma?

Answer 8

Fibrinogen
IgM
Beta lipoprotein

Question 9

What region in protein electrophoresis is important in diagnosing Multiple sclerosis

Answer 9

Gamma region

Question 10

Specific electrophoretic techniques in detecting Oligoclonal bands or monoclonal proteins

Answer 10

Immunofixation electrophoresis (IFE)

Question 11

Other conditions that may indicate or show oligoclonal bands in gamma regions:

Neurosyphilis
Encephalitis
Guillain-Barre syndrome
CNS neoplasm

T or F

Answer 11

T

Question 12

(Other Tests)

What is the normal value for CSF/Serum albumin index?

a. <0.7
b. <9
c.< 4 ng/mL
d.< 25 mg/dL
e. <8-18 mg/dL

Answer 12

b

Question 13

(Other Tests)

Increased damage to blood-brain

a. CSF/Serum albumin index
b. CSF IgG index
c. Glucose
d. MBP
e.lactate
f. Glutamine

Answer 13

a

Question 14

(Other Tests)

Unit for CSF in CSF/Serum albumin index?

Answer 14

mg/dL

Question 15

(Other Tests)

Unit for Serum in CSF/Serum albumin index?

Answer 15

g/dL

Question 16

Albumin index formula?

Answer 16

CSF alb (mg/dL) / Serum Alb (g/dL)

Question 17

IgG index formula?

Answer 17

(CSF IgG / Serum IgG) / (CSF Alb / Serum Alb)

Question 18

(Other Tests)

Decrease in Bacterial Meningitis

a. CSF/Serum albumin index
b. CSF IgG index
c. Glucose
d. MBP
e.lactate
f. Glutamine

Answer 18

c

Question 19

(Other Tests)

Increase in multiple sclerosis

a. CSF/Serum albumin index
b. CSF IgG index
c. Glucose
d. MBP
e.lactate
f. Glutamine

Answer 19

bd

Question 20

(Other Tests)

Increase in bacterial meningitis and intracranial hemorrhage

a. CSF/Serum albumin index
b. CSF IgG index
c. Glucose
d. MBP
e.lactate
f. Glutamine

Answer 20

e

Question 21

(Other Tests)

Increase in liver disorders, coma, disturbance of consiousness

a. CSF/Serum albumin index
b. CSF IgG index
c. Glucose
d. MBP
e.lactate
f. Glutamine

Answer 21

f

Question 22

(Other Tests)

What is the normal value for CSF IgG index

a. <0.7
b. <9
c.< 4 ng/mL
d.< 25 mg/dL
e. <8-18 mg/dL

Answer 22

a

Question 23

(Other Tests)

What is the normal value for MBP?

a. <0.7
b. <9
c.< 4 ng/mL
d.< 25 mg/dL
e. <8-18 mg/dL

Answer 23

c

Question 24

(Other Tests)

What is the normal value for Glutamine
a. <0.7
b. <9
c.< 4 ng/mL
d.< 25 mg/dL
e. <8-18 mg/dL

Answer 24

e

Question 25

(Other Tests)

What is the normal value for Lactate

a. <0.7
b. <9
c.< 4 ng/mL
d.< 25 mg/dL
e. <8-18 mg/dL

Answer 25

d

Question 26

Glucose vs lactate:

Inversely proportional

T or F

Answer 26

T

Question 27

Glucose is decrease in bacterial meningitis while lactate is increase

T or F

Answer 27

T

Question 28

The normal value for Glucose in CSF base it with Plasma glucose?

Answer 28

65% PS (50-80 mg/dL)

Question 29

High CSF glutamine is consistent with hyperammonemia

T or F

Answer 29

T

Question 30

> ____mg/dL level of glutamine is associated with coma and disturbance of consciousness

Answer 30

35