12a Abdomen Deep and the Digestive System Flashcards
The anus has two sphincters
- Internal anal sphincter composed of smooth muscle (involuntary-parasympathetic control)
- External anal sphincter composed of skeletal muscle (voluntary)
These sphincters are closed except during defecation
Colon
Has distinct regions: ascending colon, hepatic flexure, transverse colon, splenic flexure, descending colon, and sigmoid colon
The transverse and sigmoid portions are anchored via mesenteries called mesocolons
95% of water is absorbed in the large intestines by osmosis
Large Intestines (Teniae coli)
three bands of longitudinal smooth muscle in its muscularis
Large Intestines (Haustra)
pocketlike sacs caused by the tone of the teniae coli
-Slow segmenting movements that move the contents of the colon and sequentially contract as they are stimulated by distension
Large Intestines (Epiploic appendages)
fat-filled pouches of visceral peritoneum
Parts of Colon
Ascending Colon
Transverse Colon
Descending Colon
Sigmoid Colon-S Curve to the rectum
Rectum and anal canal
Cecum with appendix
Sac that receives waste from the small intestines and lies below the ileocecal valve
Contains a worm-like vermiform appendix (lymphatic tissue)
Presence of food in the stomach
Activates the gastrocolic reflex
Initiates peristalsis that forces contents toward the rectum
The Gallbladder
Thin-walled, green muscular sac on the ventral surface of the liver
Stores and concentrates bile by absorbing its water and ions
Releases bile via the cystic duct, which flows into the bile duct
Composition of Bile
A yellow-green, alkaline solution containing bile salts, bile pigments, cholesterol, neutral fats, phospholipids, and electrolytes
The chief bile pigment is bilirubin, a waste product of heme
Bile salts
cholesterol derivatives that:
Emulsify fat
Facilitate fat and cholesterol absorption
Help solubilize cholestero
Enterohepatic circulation
recycles bile salts
The chief bile pigment is
bilirubin, a waste product of heme
Hepatocytes’ functions include
- Production of bile
- Processing bloodborne nutrients
- Storage of fat-soluble vitamins
- Detoxification
Secreted bile flows between hepatocytes toward the bile ducts in the portal triads
Liver sinusoids
enlarged, leaky capillaries located between hepatic plates
Kupffer cells
hepatic macrophages found in liver sinusoids
Portal Triads
Hexagonal-shaped liver lobules are the structural and functional units of the liver
Composed of hepatocyte (liver cell) plates radiating outward from a central vein
Portal triads are found at each of the six corners of each liver lobule
Portal triads consist of a bile duct and
Hepatic artery – supplies oxygen-rich blood to the liver
Hepatic portal vein – carries venous blood with nutrients from digestive viscera
The ligamentum teres
Is a remnant of the fetal umbilical vein
Runs along the free edge of the falciform ligament
The falciform ligament
Separates the right and left lobes anteriorly
Suspends the liver from the diaphragm and anterior abdominal wall
Exocrine function
Secretes pancreatic enzymes
1. Trypsin- polypetides>peptides
2. Lipase- fat>fatty acids
3. Amylase- Carbohydrates>glucose
4. Nucleases –Nucleic acid>nucleotides
5. Carboxypeptidase- polypeptides>peptides
Acini (clusters of secretory cells) contain zymogen granules with digestive enzymes
Endocrine function
- Insulin –(Beta cells of Islets of Langerhans) decreases blood sugar by removing it from blood into cells
2. Glucagon- (Alpha cells)increases blood sugar by breaking down glycogen into glucose and fat.
Cystic Duct
connect the Gall bladder to the Common Hepatic Duct to form the Common Bile Duct
Main Pancreatic Duct
also known as the Duct of Wursung
Accessory Pancreatic Duct
Duct of Santorini
Ampulla of Vater
Opening of the Main Pancreatic Duct
Sphincter of Oddi
Muscle that opens and closes the Ampulla of Vater.
Pancreas
Location
Lies deep to the greater curvature of the stomach
The head is encircled by the duodenum and the tail abuts the spleen
It produces the most digestive enzymes of any organs.(1200-15OO ml of digestive enzymes per day)
It is both a exocrine and endocrine gland
Small Intestine: Histology of the Wall
Cells of intestinal crypts (Crypts of Lieberkuhn) secrete intestinal juice
Peyer’s patches are found in the submucosa
Brunner’s glands in the duodenum secrete alkaline mucus (neutralizes the acidic `chyme from the stomach.
Microvilli (brush border cells)
tiny projections of absorptive mucosal cells’ plasma membranes and also secrete digestive enzymes
Villi
fingerlike extensions of the mucosa
Plicae circulares
deep circular folds of the mucosa and submucosa, force chyme to spiral through and increase the time of absorption.
Small Intestine: Gross Anatomy
Runs from pyloric sphincter to the ileocecal valve
Has three subdivisions:
1. Duodenum- 10-12 inches
2. Jejunum- 8 feet long
3. Ileum- 11 feet long
The jejunum extends from the duodenum to the ileum
The ileum joins the large intestine at the ileocecal valve
Stomach Ulcers
Caused by the bacteria Helicobacter pylori which burrs a hole through the mucosa and allows the HCl to further irritate the lining.
1. The bacteria secrete ammonia (base) that neutralizes the HCl
2. It then secretes a cytotoxin that damages the mucosal cells
3. It then produces proteins that separate the cells tight junctions
Stomach Lining
The stomach is exposed to the harshest conditions in the digestive tract
To keep from digesting itself, the stomach has a mucosal barrier with:
a. A thick coat of bicarbonate-rich mucus on the stomach wall
b. Epithelial cells that are joined by tight junctions
c. Gastric glands that have cells impermeable to HCl
Damaged epithelial cells are quickly replaced
Mucous neck cells
secrete acid mucus
Parietal cells
secrete HCl and intrinsic factor(needed for Vitamin B12 (nucleic acid metabolism and RBC maturation) absorption in Sm. Intestines)
Chief cells
produce pepsinogen
Pepsinogen is activated to pepsin by:
HCl the stomach
Pepsin breaks down proteins to polypeptides
Enteroendocrine cells – secretes
Gastrin-stimulates gastric glands (especially HCl) to increase there secretion, stimulates gastric emptying
B. Histamine-activates parietal cells to release HCl
C. Serotonin-stimulates gastric muscle contractions
D. Cholecystokinin (CCK)-allows pancreatic and bile enzymes to be released
E. Ghrelin-release when stomach is empty stimulating hunger and appetite.
Muscularis
has an additional oblique layer that:
a. Allows the stomach to churn, mix, and pummel food physically
b. Breaks down food into smaller fragments
Epithelial lining
Goblet cells that produce a double layer coat of alkaline insoluble mucus with bicarbonate in between.