12.2: Disorders of Pulmonary Circulation Flashcards

1
Q

What happens to most of fluid that moves from vessels to interstitium?

A

Whisked away in lymphatics

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2
Q

What is another name for high pressure edema? What is the main problem with it?

A
  • Cardiogenic pulmonary edema

- Elevated LVEDP causes elevated hydrostatic pressures resulting in increased edema formation in alveoli

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3
Q

Physical exam findings in high pressure pulmonary edema?

A
  1. JVD
  2. S3
    3 Hepatomegaly
  3. Edema
  4. Good extremities
  5. Thready pulse
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4
Q

CXR signs of high pressure edema?

A
  1. Vascular engorgement
  2. Perihilar infiltrate
  3. Cephalization
  4. Kerly B lines
  5. Pleural effusion
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5
Q

Causes of high pressure edema?

A
  1. LV dysfunction
  2. Mitral valve disease
  3. Hypervolemia with normal cardiac function
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6
Q

What is cephalization?

A
  • Vessels moving towards top of lungs that are plump
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7
Q

Treatment for high pressure pulmonary edema?

A
  1. O2 mask ventilation
  2. Decrease preload: Nitrates, diuretics, venodilators
  3. Decreased afterload: ACEI, hydralazine
  4. Increase contractility: Dobutamine, milrinone
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8
Q

Another name for low pressure edema?

A
  • ARDS
  • “Acute lung injury” ALI
  • No evidence of high pressure
  • *Systemic process (usually inflammatory)Leaky capillaries leading to edema with protein [] reaching serum
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9
Q

What can cause low pressure edema?

A
  1. Trauma
  2. Sepsis
  3. Pancreatitis
  4. Inhalation injury
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10
Q

In which edema are capillaries leaky?

A
  • Low pressure

- Leads to edematous fluid that has higher [protein]

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11
Q

Problems in low pressure edema?

A

Early: Refractory hypoxemia as alveoli flood
Late: Hypercapnia

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12
Q

PE in low pressure edema?

A

Lack of finding indicating high pressure as seen in high pressure edema

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13
Q

How does swan ganz catheter work?

A

Flow takes catheter through RA, RV, PA and into pulmonary capillaries

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14
Q

Pulse pressure in high and low pressure edema?

A

Low: Wide
High: Narrow

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15
Q

Wedge pressure in high and low pressure edema?

A

HIgh: >20
Low:

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16
Q

Treatment of low pressure pulmonary edema?

A
  1. Fix underlying problem: stop inflammation
  2. Lower hydrostatic pressure
  3. Oxygen
  4. Mechanical ventilation: high peep, low tidal volume
  5. Salvage therapy: ECMO
17
Q

What is PEEP?

A

“Positive end expiratory pressure”

  • Distended alveoli preventing collapse
  • Makes interstitial space a bit negative in pressure pulling water into it
18
Q

What is ECMO?

A

“Extracorporeal Membrane Oxygenation”

  • Large catheter place in IJV to suck out blood
  • Removes CO2 and adds O2
  • Then dumps into RA
  • *Done in lung failure
19
Q

What leads to pulmonary embolism

A
  • Hypercoagulable state from venous stasis or intimal injury leading to thrombus formation
  • Clot can move proximally or DVT may dislodge and embolize
20
Q

What does pulmonary artery obstruction lead to?

A
  • Increased PVR straining right heart
  • Redistribution of flow: V/Q mismatch
  • Hyperventilation
  • RV pressure overload and ischemia
21
Q

Risk factors for pulmonary embolism?

A
  1. > 40yo
  2. Stasis
  3. History of thromboembolism
  4. Surgery
  5. Trauma: long bone fracture with fat embolism
  6. Cancer
  7. Obesity
22
Q

PE clinical presentation?

A
  • Chest pain
  • Dyspnea
  • Apprehension
  • Cough / hemoptysis
23
Q

Why is PE hard to diagnose?

A
  • Symptoms and presentation are extremely non specific
24
Q

Physiology of PE?

A
  • Well formed clot from leg shoots up and lodges in pulmonary vessel
25
Q

Diagnostic for PE?

A
  1. D dimer: good for ruling out
  2. US on lower extremity: vein does not collapse on pressure
  3. V/Q scan of lung: looking for areas that are ventilated by not perfused
  4. CT angiography
  5. Pulmonary angiogram: GOLD STANDARD
26
Q

PE therapy?

A
  1. Prevention
  2. Anticoags: Heparin / coumadin for 6 mos
    - Prevents future clots
  3. IVC filter
  4. Thrombolytics: only works in shock
    - Clots are so old and well organized that they really don’t go away
27
Q

What is normal Pulmonary artery pressure?

A
  • 10 -20
  • The RV cannot generate pressure > 40 acutely
  • Pulmonary pressure can approach systemic chronically but not without consequence
28
Q

Classifications of pulmonary hypertension?

A
  1. Primary pulmonary artery htn
  2. From left heart disease
  3. From lung disease or hypoxia: causes constriction
  4. Chronic thromboembolic pulm. htn.
29
Q

Connective tissue diseases that can cause pulm htn?

A
  1. Scleroderma
  2. Lupus
  3. HIV although not connective
30
Q

Drugs causing pulmonary embolism?

A
  1. Fenfluramine
  2. Rapeseed oil
  3. Cocaine
  4. Amphetamines
31
Q

Treatment of pulmonary htn.?

A
  1. Treat the underlying disease.
  2. Ca can channel blockers
  3. Endothelin receptor blockers (Bosentan)
  4. Cyclic GMP phosphodiesterase type 5
    inhibitors (Sildenafil)***Viagra
  5. Prostaglandins: short life so need IV
  6. Consider anticoagulation
  7. Lung Transplant
32
Q

What does oxygen dialate?

A

Only the pulmonary vessels and nothing else

33
Q

What does endothelin do?

A

Vasoconstrictor