12. β-receptor antagonists

Question 1

β-receptor antagonists

Answer 1

non selective & selective β1

Question 2

non selective β-receptor antagonists

Answer 2

Propranolol 
Pindolol 
Timolol
Carvedilol 
Labetalol 
Sotalol 
Celiprolol

Question 3

β1 selective blockers

Answer 3

cardioselective

Nebivolol 
Metoprolol 
Betaxolol 
Esmolol 
Acebutolol 
Atenolol

Question 4

Propranolol

Answer 4

highest lipid solubility

local anesthetics effect (NA+ channel blocked)

Question 5

Pindolol

Answer 5

partial agonist (ISA) 
local anesthetics  effect (NA+ channel blocked)

Question 6

Carvedilol & Labetalol

Answer 6

also blocks α1 => vasodilation

dual effect in hypertension

Question 7

Sotalol

Answer 7

lowest lipid solubility

K+ channel blocker => antiarrhythmic

Question 8

Nebivolol

Answer 8

highest lipid solubility
very long half life (10hr)
leads to vasodilation by NO

Question 9

Metoprolol

Answer 9

local anesthetics effect (NA+ channel blocked)

Question 10

Betaxolol

Answer 10

very long half life (20hr)

Question 11

Esmolol

Answer 11

very short half life (10min)

Question 12

Acebutolol

Answer 12

partial agonist (ISA) 
lowest lipid solubility 
local anesthetics  effect (NA+ channel blocked)
also cues NA+ channel blocking

Question 13

Atenolol

Answer 13

lowest lipid solubility

Question 14

ISA

Answer 14

intrinsic sympathomimetic activity

a group of beta blockers that are able to stimulate beta-adrenergic receptors (agonist effect) and to oppose the stimulating effects of catecholamines (antagonist effect) in a competitive way