1.2 Phoshorylation

Question 1

Describe the reversible binding of phosphates

Answer 1

The addition or removal of phosphate can cause reversible conformational changes in proteins
This is a common form of post translational modification

Question 2

Describe the role of Protein Kinases

Answer 2

Protein kinases add a phosphate group to other proteins
It is the TERMINAL phosphate of ATP that is transferred to specific R groups in the protein

Question 3

Describe the role of protein phosphatases

Answer 3

They catalyse the removal of a phosphate from a protein

Question 4

What charge does adding a phosphate group give

Answer 4

A negative charge

Question 5

Phosphorylation brings about …..

Answer 5

Conformational changes which affect a proteins activity

Question 6

What impact does adding a phosphate group have on ionic interactions

Answer 6

A negative charge is added
Ionic interactions normal in the unphosphorylated protein may be disrupted and New Ionic interactions may be created