11.2 reception Flashcards
the signaling molecule behaves like a
ligand
ligand
a molecules that specifically binds to another molecule
- causes receptor protein to change in shape
- or causes 2 receptor molecules to aggregate together
signal receptors in the plasma membrane are
water soluble and too large to pass through the plasma membrane
how do membrane proteins work
-water soluble signal binds to specific site in membrane
- shape changes
- or aggregates transmitting info (from the external environment)`
where are intracellular receptors
in the cytoplasm or nucleus in target cells
signal molecules for intracellular receptors
- hydrophobic or small enough to pass through phospholipid bilayer in plasma membrane
- steroids, thyroid hormones, nitric oxide (NO) -gas
3 major types of plasma membrane receptors
G protein coupled receptors
receptor tyrosine kinases
-ion channel receptors
3 common types of intracellular receptors
-steroids,
thyroid hormones,
nitric oxide (NO) -gas
how odes testosterone work
- intracellular steroid is
- secreted by testes-> blood -> cells
- binds to receptor proteins
- hormone/ protein complex changes shape and enters nucleus
- controls male gender characteristics
what proteins control whether or not a gene is transcribed
transcription factors
- testosterone was a transcription factor after it went into the nucleus
- it turns on specific genes to be transcribed (by binding to them)
G protein coupled receptors
-plasma membrane receptor that works with a G protein to bind GTP (energy molecule)