111814 viruses Flashcards
influenza viruses A, B can cause what diseases
rhinitis pharengitis croup bronchitis bronchiolitis pneumonia
rhinoviruses can cause what kind of diseases
rhinitis
pharengitis
respiratory viruses
influenza rhinovirus enteroviruses coronavirus parainfluenza virus RSV metapneumonovirus adenovirus
which viruses can have viremia?
measles
adenovirus
enteroviruses
enteroviruses
measles
EBV
HSV
CMV
pathogenesis of influenza
virus replication-destruction of respiratory epithelium
cell damage also due to virus activated cytotoxic T cells
decreased clearance
risk of bacterial infec
systemic symptoms of influenza A and B are caused by
interferon and cytokine response to virus
antiviral therapy
zanamivir, oseltamivir
they’re neuraminidase inhibitors
what viruses cause summer colds and “flu”
enteroviruses
get common cold symptoms
fever, headache, fatigue
what do coronaviruses cause?
common colds (second most prevalent cause)
SARS
MERS (acute severe pneumonia, renal failure)
when do parainfluenza virus infec usually occur
fall, winter
RSV pathogenesis
blockage of narrow airways of INFANTS (virus induced CPE includes syncytia-multinucleated cells. induction of inflam cytokines)
infects virtually everyone by age 2
natural infec don’t prevent RE-infection
clinical consequences of RSV infec
bronchiolitis, pneumonia, or both (in children younger than 1 yr)
febrile rhinitis and pharyngitis (children)
common cold (older children, adults)
what can premature infants get for prevention of RSV infec?
passive immunization with anti-RSV Ig and humanized monoclonal antibodies
metapneumovirus
clinical spec of disease similar to RSV but in general milder
by 5 yrs of age, almost all children have had it
Hendra and Nipah viruses
paramyxoviruses
emerging, high mortality rates
made the jump from bats to people with pigs
adenovirus
causes wide spectrum of disease (pharyngitis, conjunctivitis pink eye, GI, hemorrhagic cystitis-inflam of urinary bladder)
in RT, can cause productive infection, persistent infection with virus shedding, or latent infections in lymphoid tissues like tonsils
adenovirus-prevention and control?
no adenovirus vaccine for general public. new live attenuated vaccine was approved for military recruits
cidofovir for immunocompromised
measles virus symptoms
maculopapular rash COUGH CONJUNCTIVITIS CORYZA 3 C's
photophobia Koplik spots (inside cheeks, white)
complications of measles
otitis media
croup
pneumonia
measles virus is of what family
paramyxovirus
DNA viruses for respiratory dis
adenovirus
herpesvirus (EBV, CMV, HSV)
RNA viruses for respiratory dis
picornavirus (rhinovirus, enterovirus)
coronavirus (coronavirus, SARS, MERS)
orthomyxoviridae (influenza A, B, C)
paramyxoviridae (parainfluenza, RSV, metapneumovirus, measles, Hendra, Nipah)
