111714 pulm vasc

Question 1

risk factors for venous thromboembolism

Answer 1

thrombophilias
stasis
injury

medical risks-hip or knee surgery, immobility, CHF, obesity, etc

Question 2

60-90% of pulmonary embolisms originate from where

Answer 2

proximal deep veins of legs (popliteral v and above)

Question 3

chronic thrombotic, embolic disease is classified under what group for pulmonary HTN?

Answer 3

group IV

Question 4

classification of pulm HTN-chronic disorders

Answer 4

I: pulm arterial HTN
II: pul venous HTN, left heart (most common)
III: pulm HTN, respiratory disorders (FVC under 70%)
IV: pulm HTN, chronic thromboembolic disorders
V: pulm HTN, miscellaneous

Question 5

definition of PAH

Answer 5

mean pulm arterial pressure greater than 25 mm Hg at rest with a normal wedge pressure

Question 6

causes of pulmonary arterial HTN

Answer 6

idiopathic
heritable (BMPR2 genetic mutations, others)

also associated sometimes with other things

Question 7

BMPR2

Answer 7

bone morphogenic protein receptor 2

Question 8

plexiform lesion in small vessel is specific to what disease?

Answer 8

group I PAH diseases

Question 9

3 main pathways targeted for therapy for PAH

Answer 9

endothelin pathway
ntiric oxide pathway
prostacyclin pathway (vasodilation)

Question 10

pulmonary vasculitis manifestations

Answer 10

pulmonary and alveolar hemorrhage
lung infiltrates
pulmonary HTN

Question 11

alveolar (capillary) hemorrhage syndromes

Answer 11

antibasement membrane antibody disease (good pastures)

ANCA associated vasculitis

idiopathic pulmonary hemosiderosis

collagen vascular diseases (SLE)

Question 12

classic triad of alveolar (capillary) hemorrhage syndromes

Answer 12

hemoptysis
pulmonary infiltrates
anemia