11. Adrenergic Drugs

Question 1

finish the mneomonic

Q I S S

Answer 1

a1=Gq
a2=Gi
b1=Gs
b2=Gs

Question 2

Gq
Gi
Gs
What are the downstream effects?

Answer 2

Gq = PLC, PIP2, IP3 and DAG, inc Ca, PKC
Gi= dec AC, cAMP inhibition
Gs= inc. AC, cAMP, PKA

Question 3

What are the main actions of a1 adrenergic activation? (4)

Answer 3

vascular smooth muscle contraction
Pupillary dilator muscle contraction (dilates)
Prostate contraction
Heart increases force contraction

Question 4

What are the main actions of a2 adrenergic activation? (4)

Answer 4

Platelet aggregation
AR/AChR inhibit transmitter release
Vascular SM contraction
Fat Cells - inhibit lipolysis

Question 5

What are the main actions of b1 adrenergic activation? (2)

Answer 5

Heart increases force/rate of contraction

Juxtaglomerular cells inc. renin release

Question 6

What are the main actions of b2 adrenergic activation? (3)

Answer 6

Resp/uterine/ vascular SM: SM relaxation
Skeletal Muscle: potassium uptake
Human liver: activates glycogenolysis and gluconeogenesis

Question 7

What are the main actions of b3 adrenergic activation?(2)

Answer 7

Bladder relaxes detrusor m

Fat cells activate lipolysis

Question 8

What are the main actions of D1 adrenergic activation? 1

Answer 8

Smooth M: dilates renal BV

Question 9

What are the main actions of D2 adrenergic activation? (1)

Answer 9

Nerve endings: modulates transmitter release