10. CIS Pharmacodynamics

Question 1

How do you calculate therapeutic (safety) index?

Answer 1

TI = TD50/ED50

Question 2

The higher the TI (therpeutic index) the….?

Answer 2

safer the drug

Question 3

If drug A is a partial agonist and drug B is a full agonist, what is true?

Answer 3

Drug A has a lower Emax than Drug B b/c full agonists produce maximal effects and partial produce submaximal effects

Question 4

If a drug increases HR alone, but with another highly effective B- adrenergic it causes a decrease in HR, what should the drug be classified as?

Answer 4

Partial agonist (makes drug not acheive Emax) - this is because the partial agonist displaced the full agonist on the receptor, causing a decrease in the increase of HR

Question 5

What changes for a non-competitive agonist?

Answer 5

Emax decreases, EC50 does not change

Question 6

What changes for a competitive agonist?

Answer 6

Emax does not change, EC50 increases

Question 7

Once and IFN binds to a receptor, what is activated next?

Answer 7

Cytosolic tyrosine kinases (and/or JAK which are coupled to Receptor tyrosine kinases)