1002 2nd Pdf

Question 1

Cells are bound to one another by

Answer 1

Cell-cell junctions

Question 2

Epithelial tissue is abundant

Answer 2

More than 60% are epithelial

Question 3

Functions of cell-cell junctions

Answer 3

1- forms barriers lumen and blood
2- cell to cell attachment (adhesion)
3- cell to cell communication (gap junctions)

Question 4

Cell-cell junctions

Answer 4

1 occluding
2 anchoring
3 channel forming

Question 5

Tight junction =

Answer 5

Zonula occludes

Question 6

Occluding junction function

Answer 6

1- seals neighboring cellsto prevent passage of molecules
2- separates the apical and base lateral domains

Question 7

Tight junctions are located in

Answer 7

Below the apical surface

Question 8

Do membranes fuse

Answer 8

The do not fuse

Question 9

Claudine and occluding associate with ZO

Answer 9

That links the junction to the actin cytoskeleton

Question 10

Tight junction are responsible for

Answer 10

1- blood-brain
2- blood-lestes

Question 11

Endothelia) cells in the brainare joined with the spinal cord by

Answer 11

Tight junctions

Question 12

Claudia 16 mutations cause a rare human

Answer 12

Renal magnesiumwasting syndrome - hypomagnesemia

Question 13

Claudin 14 causes

Answer 13

Hereditary deafness

Question 14

Anchoring junctions =

Answer 14

Adhering

Question 15

Adhering junctions function

Answer 15

1- cell to cell adhesion
2- binding of cytoskeleton to the cell surface

Question 16

Forms of anchoring junctions

Answer 16

1- adherens _ actin filaments
2- desmosomes - intermediate filaments

Question 17

Protein classes in anchoring junction

Answer 17

1- cell-cell adhesion proteins (transmembrane)- cadherins (cell to cel).
- interns cell to matrix
2- intracellular anchor proteins catenin, vinculin, desmoglein, desmocollin)

Question 18

Strongest pointsof cell adhering is

Answer 18

DeSmosome’s and providemechanical binding

Question 19

DeSmosome’s are in

Answer 19

Epidermis skin
Heart muscle
Neck of the uterus

Question 20

Adhering profien family

Answer 20

Desmoglein, desmocollin

Question 21

Plaque proteins are

Answer 21

Makoglobins, desmoplakins / plakophilins

Question 22

The plaque link the

Answer 22

Cadherins

Question 23

Plakoglobin mutation

Answer 23

Naxos, ARVC

Question 24

Desmoplakin mutation

Answer 24

ARVC

Question 25

Intermediate filaments types

Answer 25

Epithelial cells → keratin
Heart and muscle →desmin

Question 26

Blood cells and skeletal muscle cells

Answer 26

Gap junction do not occur

Question 27

Tube like protein are in

Answer 27

Gap junctions

Question 28

Permeability of gap junctions

Answer 28

Small ✓
Macro no

Question 29

Gap junction function

Answer 29

1-They are the site of firm adhesion of cells
• 2-principal and only type of junction that allows free interchange of substances
• 3-Have an Important role in the regulation of intrauterine development and differentiation
+
• 4-It is important in the coordination of function among groups of cell

Question 30

Connexin-25ß2 mutation

Answer 30

Human deafness
Heart malformation