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Pathology I > 10: wound healing > Flashcards

10: wound healing Flashcards

1
Q

restoration of tissue architecture and function after an injury

A

wound healing

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2
Q

wound healing v. repair

A
  • wound healing indicates regeneration

- repair: functional compromise

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3
Q

original archtecture and structure of an organ or anatomic part is compeletey restored

A

wound healing

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4
Q

outcome is not anatomic restoration but a functional compromise

A

wound repair

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5
Q

chances of regeneration are excellent

A

labile cells

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6
Q

healing by scarring only

A

permanent cells

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7
Q

chances of regeneration are good

A

stable cells

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8
Q

stable cell examples

A

liver and kidney

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9
Q

tissue not capable of regeneration

A

brain neurons
cardiac muscle
skeletal muscle

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10
Q

clot formation and chemotaxis

A

inflammation phase

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11
Q

re-epithelization

A

proliferation phase

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12
Q

angiogenesis and granulation tissue

A

proliferation

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13
Q

provisional matrix

A

proliferation phase

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14
Q

collagen matrix and wound contraction

A

maturation phase

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15
Q

major regulatior factor of angiogenesis

A

VEGF

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16
Q

capillary budding via endothelial cell proliferation

A

angiogenesis

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17
Q

major stimulatory factor of fibrogenesis

A

TGF-beta

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18
Q

fibroblast activation and proliferation causing collagen deposition

A

fibrogenesis

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19
Q

what is the director of wound healing

A

macrophage

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20
Q

specialized type of tissue characteristic of healing

A

granulation tissue

21
Q

pink, soft, granular gross appearance

A

granulation tisseu

22
Q

proliferation of fibroblasts and think-walled delicate capillaries in a loose ECM

A

granulation tissue

23
Q

how does scarring occur

A

granulation tissue progresively accumulates connective tissue matrix eventually resulting in dense fibrosis (scarring) which may further remodel over time

24
Q

granulation tissue consists of …

A

fibroblasts surrounded by abundant ECM, newly formed blood vessels, and scattered macrophages and some other inflammatory cells

25
Q

numerous macrophages, myofibroblasts and blood vessels

A

early granulation tissue

26
Q

less vascular, only scattered macrophages with more matrix and fibroblasts

A

late granulation tissue

27
Q

blue green on trichrome stain

A

fibrosis/collagen

28
Q

First intention healing

A

margins of wound apposed adn healing occurs directly with minimum of granulation tissue

29
Q

epithelial regenration proedominates over fibrosis

A

healling by first intention

30
Q

non-appposed wound margins that rquire more tissue removal and more granulation tissue be formed in healing

A

healing by second intention

31
Q

wound contraction within — wks

A

6 wks via myofibroblasts

32
Q

reduction in the size of a wound that is healed by 2nd intention as a result of the action of myofibroblasts

A

wound contraction

33
Q

an exaggeration of contraction

A

contracture

34
Q

have hybrid properties of fibroblasts and smooth muscle cells

A

myofibroblasts

35
Q

can produce collagens and other ECM prtns but also can contract

A

myofibroblasts

36
Q

how are myofibroblasts good?

A

important for the contraction of wound and the prevention of dehiscence

37
Q

the most common cause of delayed wound healing

A

infection

38
Q

excess corticosteroids..

A

slow healing (think anti-inflammatory therapy)

39
Q

bed sores

A

ischemia due to pressure produces decubitus ulcers (no blood flow for healing)

40
Q

prominent raised scars, accumulation of exuberant amounts of collagen

A

keloids

41
Q

excessive granulation tissue, preventing wound closure

A

exuberant granulation tissue (proud flesh)

42
Q

hyperplastic scar composed of irregular depositied bundles of collagen

A

keloid

43
Q

hypotrophic scar

A

sunken and hyperpigmented appearance due to a loss of collagen and ground substance

44
Q

acne marks and stretch marks of pregnancey

A

hypotrophic scars

45
Q

how is a hypertrophic scar different form a keloid scar

A

a hypertrophic scar never gets worse beyond 6 months

46
Q

if you excise a hypertrophic scar will it return?

A

no - but a keloid will

47
Q

more likely to grow some time after the event and with no tendency to subside

A

keloid

48
Q

excesive bleeding when bumbled

A

proud flesh

49
Q

in a skin ulcer, excessive granulation tissue rising higher than the epidermis

A

proud flesh

Pathology I (12 decks)

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