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Pathology I > 10: wound healing > Flashcards

10: wound healing Flashcards

1
Q

restoration of tissue architecture and function after an injury

A

wound healing

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2
Q

wound healing v. repair

A
  • wound healing indicates regeneration

- repair: functional compromise

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3
Q

original archtecture and structure of an organ or anatomic part is compeletey restored

A

wound healing

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4
Q

outcome is not anatomic restoration but a functional compromise

A

wound repair

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5
Q

chances of regeneration are excellent

A

labile cells

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6
Q

healing by scarring only

A

permanent cells

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7
Q

chances of regeneration are good

A

stable cells

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8
Q

stable cell examples

A

liver and kidney

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9
Q

tissue not capable of regeneration

A

brain neurons
cardiac muscle
skeletal muscle

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10
Q

clot formation and chemotaxis

A

inflammation phase

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11
Q

re-epithelization

A

proliferation phase

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12
Q

angiogenesis and granulation tissue

A

proliferation

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13
Q

provisional matrix

A

proliferation phase

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14
Q

collagen matrix and wound contraction

A

maturation phase

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15
Q

major regulatior factor of angiogenesis

A

VEGF

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16
Q

capillary budding via endothelial cell proliferation

A

angiogenesis

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17
Q

major stimulatory factor of fibrogenesis

A

TGF-beta

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18
Q

fibroblast activation and proliferation causing collagen deposition

A

fibrogenesis

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19
Q

what is the director of wound healing

A

macrophage

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20
Q

specialized type of tissue characteristic of healing

A

granulation tissue

21
Q

pink, soft, granular gross appearance

A

granulation tisseu

22
Q

proliferation of fibroblasts and think-walled delicate capillaries in a loose ECM

A

granulation tissue

23
Q

how does scarring occur

A

granulation tissue progresively accumulates connective tissue matrix eventually resulting in dense fibrosis (scarring) which may further remodel over time

24
Q

granulation tissue consists of …

A

fibroblasts surrounded by abundant ECM, newly formed blood vessels, and scattered macrophages and some other inflammatory cells

25
numerous macrophages, myofibroblasts and blood vessels
early granulation tissue
26
less vascular, only scattered macrophages with more matrix and fibroblasts
late granulation tissue
27
blue green on trichrome stain
fibrosis/collagen
28
First intention healing
margins of wound apposed adn healing occurs directly with minimum of granulation tissue
29
epithelial regenration proedominates over fibrosis
healling by first intention
30
non-appposed wound margins that rquire more tissue removal and more granulation tissue be formed in healing
healing by second intention
31
wound contraction within --- wks
6 wks via myofibroblasts
32
reduction in the size of a wound that is healed by 2nd intention as a result of the action of myofibroblasts
wound contraction
33
an exaggeration of contraction
contracture
34
have hybrid properties of fibroblasts and smooth muscle cells
myofibroblasts
35
can produce collagens and other ECM prtns but also can contract
myofibroblasts
36
how are myofibroblasts good?
important for the contraction of wound and the prevention of dehiscence
37
the most common cause of delayed wound healing
infection
38
excess corticosteroids..
slow healing (think anti-inflammatory therapy)
39
bed sores
ischemia due to pressure produces decubitus ulcers (no blood flow for healing)
40
prominent raised scars, accumulation of exuberant amounts of collagen
keloids
41
excessive granulation tissue, preventing wound closure
exuberant granulation tissue (proud flesh)
42
hyperplastic scar composed of irregular depositied bundles of collagen
keloid
43
hypotrophic scar
sunken and hyperpigmented appearance due to a loss of collagen and ground substance
44
acne marks and stretch marks of pregnancey
hypotrophic scars
45
how is a hypertrophic scar different form a keloid scar
a hypertrophic scar never gets worse beyond 6 months
46
if you excise a hypertrophic scar will it return?
no - but a keloid will
47
more likely to grow some time after the event and with no tendency to subside
keloid
48
excesive bleeding when bumbled
proud flesh
49
in a skin ulcer, excessive granulation tissue rising higher than the epidermis
proud flesh

Pathology I (12 decks)

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