10. Vascular Disease Flashcards
innermost layer of artery
endothelium
atherosclerosis
response to vessel wall injury
atherosclerosis results in
endothelia dysfunction
indication of vascular disease
claudication
aneurysm
abnormal weakening of vessel wall
dissection
tear in intima allows blood into extra luminal channel
does an aneurysm or dissection have false lumen?
dissection
risk factors for thoracic aortic disease
HTN
geriatric
atherosclerosis
genetic predisposition
smoking
genetic predisposition for thoracic aortic disease
connective tissue disorders
bicuspid aortic valve
primary causes of thoracic aortic disease
genetic
- connective tissue
- bicuspid aortic valve
stanford A
ascending involved
Stanford B
ascending not involved
abdominal aortic disease primary causes
lifestyle causing atherosclerosis
goal ACT for vascular cases
200-300s
heparin initial dose for vascular cases
100U/kg
indications for surgery in thoracic aortic aneurysm
symptomatic
>5cm diameter
growth >10mm/year
ascending and aortic arch dissection requires
urgent surgery
descending thoracic aortic dissection indications for surgery
diameter >5.5cm
rarely urgent
Type A repairs
bypass
deep hypothermia
circ arrest
thoracic aorta surgery risk
spinal cord ischemia risk increased for paraplegia with cross clamp > 30 mins
what side should you put the radial art line into for thoracic repair?
Right - shows perfusion to brain
thoracic aneurysm BP
above clamp: MAP 100 mmHg
below clamp: MAP > 50 mmHg
clevidipine
CCB
clevidipine dose
2mg/hr
(MAX: 32mg/hr)
3 ways to preserve neuro function during thoracic aneureysm repsir
- SSEP/EEG monitoring
- spinal cooling w/iced epidural
- CSF drain
induction drugs for thoracic aneurysm
minimize HTN
- versed
- propo
- narcotic (sufentanil)