10/19- Pathology Review Flashcards
What is seen here?
Viral esophagitis (typical of herpes):
- Margination of chromatin
- Nuclear molding
- Multinucleate
Also ground glass appearance of nuclei and necroinflammatory debris (ulcer)
What is seen here?
Viral esophagitis (typical of herpes):
- Margination of chromatin
- Nuclear molding
- Multinucleate
Also ground glass appearance of nuclei
What is seen here?
Fungal esophagitis- Candida
- Pseudohyphae in squamous cells
- Yeast forms
Recall: Candida is part of flora in oral cavity; if just sitting in lumen, it’s probably contaminant. Must diagnose by seeing within tissue
What is seen here?
Barrett’s esophagitis (intestinal metaplasia)
- Can see goblet cells
- This is at the GEJ
- Predisposition to developing adenocarcinoma
What is seen here?
Adenocarcinoma
- Cells with dark nuclei with different shapes and sizes
- Gland formation
What is seen here?
Squamous cell carcinoma
- May be hard to differentiate adenocarcinoma and squamous sometimes, but as general rule, if you don’t have glands and do have tight junctions, think squamous
What is seen here?
Stomach (body/oxyntic) mucosa
What is seen here? (what cells)?
Stomach (body/oxyntic) mucosa
- Pink = parietal cells; secrete acid
- Blue = chief cells; secrete pepsinogen
What is seen here?
Antral (cardiac mucosa)
What is seen here?
Iron pill ischemia
- Can see inflammatory cells
- Brown material in surface of epithelium
What is seen here?
Iron pill ischemia
- Has ulcerated
- Brown refractile material from iron pill
What is seen here?
Autoimmune gastritis; chronic active gastritis
- Lymphoid follicles
- Think H pylori until proven otherwise?
What is seen here?
Autoimmune gastritis; chronic active gastritis
- Neutrophils infiltrating epithelial cells
- Associated with H. pylori
What is seen here?
H. pylori spiral bacilli
- Chronic active carditis is associated with H. pylori
What is seen here?
Stomach with intestinal metaplasia
- Goblet cells
What is seen here?
Adenocarcinoma: Intestinal (bulky) type
- Glands present of different size and shape
What is seen here?
Adenocarcinoma: Intestinal (bulky) type
- Many mitotic figures
- Enlarged nuclei of different size and shape
What is seen here?
Adenocarcinoma: poorly differentiated type
- Signet ring cells: mucin filling pushing nuclei to periphery