10-18c Changes to Pediatric Bone & Muscle Flashcards
What factors affect skeletal growth, size, volume, structure, and function of the skeleton?
Growth, size, vol., structure, and function depend upon: Hormones Metabolic factors Nutrition Mechanical Forces over time Genetics Disease or Pathologic processes
growth: m. activation and activity
development and function: bone growth
What are the biochemical components of bone growth? What do they contribute to?
Growth Hormone, Insulin-like growth factor: longitudinal bone growth and mass
GH deficiencies: ^BMD
IGF also important for maitenance of BMC in adulthood
puberty and sex hormones: bone growth and development
TH: direct impact on bone metabolism (hypothyroidism = decreased bone lengthening
What do sex hormones (estrogens and androgens) lead to at puberty?
rapid longitudinal bone growth, fusion of physis, increased lean body mass, and contribute to significant variability
What are the growth factors in the bone? What do they do?
FGF: continually regulate skeletal patterning and bone growth throughout the skeletal growth period
What do vitamin D and calcium do?
Vitamin D becomes 125D, which is critical for intestinal absorption of Ca and ionic phosphate
What is limiting about Ca?
only 500 mg can be absorbed at one time
What measurements are key factors in age, growth, and development?
height, weight, BMI, skeletal maturity and sexual maturity
What are the typical growth scales based on?
height, weight, BMI
growth timing and velocity
What technique determines skeletal maturity/bone age?
All use left hand and wrist
Atlas technique of Greulich and Pyle: modal maturity indicators described for a specific age
What determines bone growth?
stature, growth velocity, timing, mass, and density
When do females reach peak height?
15 YO
When do females see an increase in growth velocity (height)?
from 9.5 to 10 YO
velocity is ~3.5 in/yr
When do males reach peak growth height?
18 YO
When do males increase in growth velocity (height)?
11.5 to 13 YO
velocity is ~3.7 in/year
When do females see closure of physis?
12.5 to 18 YO
When do males see closure of physis?
15-=> 18 YO
When do females reach peak bone growth velocity and completion of fusion?
11.5 YO