1: Genital Tract Infection - STIs Flashcards
What are the 8 STIs
- Gonorrhoea
- Chlamydia
- HSV
- HIV
- Genital Warts
- Syphillis
- Trichomonas vaginalis
- PID
What are 2 non-sexually transmitted infections
- Bacterial vaginosis
2. Vulval candidiasis
How will discharge present in vulvovaginal candidiasis
Thick white curdle discharge
Aside from curd-like discharge what are two other symptoms of vulvovaginal candidiasis
Itchy vulva
Superficial dyspareunia
How can candidiasis be investigated for
Vaginal pH on exam
How is candiasis managed
Co-trimoxazole
What discharge is present in trichomonas vaginalis
Green-yellow discharge
What may be seen OE in trochomonas vaginalis
Strawberry cervix
Aside from green discharge, what are 3 other symptoms of TV
- Dysuria
- Dysparuia
- Pruritus
How is TV investigated
High vaginal-swab
How is TV managed
Metronidazole
What discharge will be present in bacterial vaginosis
Fishy-discharge
What are two tests for BV
High vaginal swab
Koh Whiff Test
How is BV managed
Metronidazole
What % of chlamydia is asymptomatic
70
How may chlamydia present
- Deep Dyspareunia
- Intermenstrual bleeding
- Post-coital bleeding
How is chlamydia diagnosed
Vulvovaginal swab for NAAT
How is chlamydia managed
Azithromycin
In what % is gonorrhoea asymptomatic
50
How may discharge in gonorrhoea present
Thin green-yellow discharge
What are symptoms of gonorrhoea
Dysuria
Dyspareunia
IM bleeding
Post-coital bleeding
How is gonorrhoea diagnosed
Endocervical swab for NAAT
How is gonorrhoea managed
IM Ceftriaxone
How does herpes present clinically
- Painful red blisters
- Abnormal discharge
- Fever
- Myalgia
How is herpes diagnosed
PCR
How is herpes managed
Acyclovir
How does a genital wart present clinically
Fleshy discolouration of skin
What may be used to look for genital warts
Colposcopy
Protoscopy
How does syphillis present initially
Primary chancre
What is used to investigate syphillis
Dark ground microscopy
What type of pelvic pain does chlamydia cause
Deep dyspareunia
What type of pelvic pain does trichomonas vaginalis cause
Superficial dyspareunia
What type of pelvic pain does gonorrhoea cause
Deep dyspareunia
What type of pelvic pain does pelvic inflammatory disease cause
Deep dyspareunia
What are 3 causes of urethras discharge in males
Chalmydia
Gonorrhoea
TV
What is the most common STI in the UK
Chalmydia
Explain contact tracing
Clinician has conversation with individual about informing own partners (patient referral) or getting anonymous source to inform the, (provider referral)
What is vulvovaginal candidiasis also known as
Thrush
What is vulvovaginal candidiasis
Fungal infection of lower female genital tract
What is the peak age for vulvovaignal candidiasis
20-40years
How common is vulvovaginal candidiasis
Common
What causes 90% of vulvovaginal candidiasis
Candida albicans
What are 5 risk factors for vulvovaginal candidiasis
- Diabetes
- Corticosteroids
- Immunosuppression (HIV, Malignancy)
- Broad-spectrum antibiotics
- Pregnancy
Why are broad-spectrum antibiotics a risk factor for vulvovaginal candidiasis
Destroys normal flora permitting overgrowth of candida
What is the main symptom of vulvovaginal candiasis
Pruritic vulva
How else may vulvovaginal candiasis present
Thick curd-like white discharge
Superficial dysuria - due to irritation skin
How will vulva appear on exam in vulvovaginal candidiasis
Erythematous and Oedematous
What are satellite lesions
Red, pustular lesions with superficial pseudomonas plaques that can be scraped off
Where is candida albicans found normally
Normal flora of GI tract
How is vulvovaginal candidiasis normally diagnosed
Clinical. However, if women examined vaginal pH should be measured
If the women is examined in vulvovaginal candidiasis, what is recommended
Vaginal pH
what is first-line for vulvogvaginal candidiasis
Vaginal anti-fungal (Co-trimoxazole, Fenticonazole)
what is second-line for vulvovaginal candidiasis
Oral anti-fungal (fluconazole, itraconazole)
when should topical imidazole for vulvovaginal candidiasis only be prescribed
If in conjunction with vaginal or oral treatment
what is a note when using anti-fungal treatments
Anti-fungal treatments are oil based and there do
why is there an increased risk of vulvovaginal candidiasis In pregnancy
Increased oestrogen
explain management of vulvovaginal candidiasis in pregnancy
Vagina co-trimoxazole and topical imidazole for vulva. NEVER give oral anti-fungals
what is trichomonas vaginalis
anaerobic protozoan
how is trichomonas vaginalis transmitted
sexual intercourse
what are 4 risk factors for trichomonas vaginalis
- Unprotected intercourse
- Multiple partners
- History STIs
- Age - older women have a higher risk
how do most people with trichomonas vaginalis present
Asymptomatic
in what time period after sexual intercourse do symptoms of trichomonas vaginalis present
28d
what are 5 symptoms of TV in women
- Vaginal odour
- Green-Yellow discharge
- Vulval pruritus
- Dyspareunia
- Dysuria
how will the cervix present in TV
Strawberry cervix
what is a strawberry cervix
Punctate and papilliform appearance of the cervix
what are symptoms of TV in males
Urethral discharge
Dysuria
Frequency
what are 2 signs of TV in males
Urethral discharge
Balanoposthitis = enlargement glans penis
can TV be transmitted through oral and anal sex
No
can TV be transmitted vertically
Yes - rare
how is TV investigated for in females
vaginal swab of posterior fornix
how is TV tested for in males
- urethral swab
- first void urine sample
explain sexual intercourse when being treated for TV
- do not have sexual intercourse during treatment
- abstain for one week if taken single dose metronidazole
what is used to manage TV
Metronidazole as:
- Single dose PO (2g)
- 400mg BD for 5-7d
what does TV in pregnancy increase risk of
- Maternal Post-partum sepsis
- Pre-mature labour
what is used to treat TV in pregnancy
Metronidazole
what is the risk with metronidazole in pregnancy and how is this overcome
Changes taste of breast milk
Do not breast feed for 12-24h after last dose
what is bacteria vaginosis
non-STI genital tract infection
what is the most common cause of vaginal discharge in women
BV
in which ethnicity is BV more common
afro-carribean
what organism causes BV
Gardenella Vaginosis
explain pathophysiology of BV
When normal flora are killed, including lactobacilli, means acid is no longer produced causing increase in vaginal pH and overgrowth of gardnerella vaginosis
what are risk factors for BV categorised into
Factors that lead to change in vaginal pH
what are 5 risk factors for BV
Sexual activity - new partner or multiple Showergel Smoking STI Receptive Oral Sex IUD Recent antibiotic use
what. % of individuals are asymptomatic with BV
50
what are the symptoms of BV
- Fishy like vaginal discharge
what are the signs of BV
- With-Grey discharge
what is the first investigation for BV
High vaginal swab
what type of cells will be seen in BV
Clue cells
Pus cells
what are clue cells
Epithelial cells that contain cocci
what is another test for BV not used in clinical practice
Koh Whiff test
what does the KOH whiff test entail
add alkali to the vaginal discharge - if gardenella is overgrown will cause fishy vaginal odour
what are 3 conservative methods for BV
- No vaginal douching
- Remove IUD
- Avoid shower gels on vagina
what is a pharmacological method for BV
Metronidazole: 2g one off dose OR 400-500mg BD for 5-7d
what does BV in pregnancy increase risk of
Pre-maturity
Miscarriage
Chorioamnionitis
what is treatment of BV in pregnancy
Metronidazole:
what are risks of metronidazole in puerperium
Metronidazole changes taste breast milk - do not breast feed 12-24h after taking
what is chlamydia
STI causes by infection with chlamydia trichomatis
what is the most common STI in the UK
Chlamydia trichomatis
how is chlamydia transmitted
STI : vaginal, oral and anal
what are 5 risk factors for chlamydia infection
- New sexual partner
- +ve sexual partner
- Multiple partners
- Lack of barrier contraception
- <25-years
- Other STI
what. % of chlamydia is asymptomatic in women
70
what % of chlamydia is asymptomatic in men
50
how long does it take for symptoms to appear after unprotected sexual intercourse for chlalmydia
7-21d
what are 5 symptoms of chlamydia in women
- Discharge
- Inter-menstrual bleeding
- Post-coital bleeding
- Deep dyspareunia
- Low abdominal pain
- Dysuria
what may be seen on examination in chlamydia in women
Chandelier sign
Cervicitis with contact bleeding
what is chandelier sign
Cervical excitation = severe pain on palpating the cervix
what are symptoms of chlamydia in men
Urethritis: dysuria and frequency
Epididymo-orchitis
how does chlamydia conjunctivitis present
Red-pink eye
how does chlamydia infection of the rectum present
Discharge
Discomfort
how does chalmydia infection of the pharynx present
Asymptomatic
What type of organism is chalmydia trachomatis
Intracellular gram-negative
What chlamydia serotypes cause genital infection
D-K
Where are chalmydia tests available from
GP
GUM
Sexual Health Clinic
What is first-line investigation in women for chalmydia
Vulvovaginal swab for NAAT
What is performed on vulvo-vaginal swab
NAAT
What is first-line to investigate for chlamydia in men
First-pass urine sample for NAAT
What should all patients presenting with chalmydia have and why
Full STI Screen - due to increased risk other STIs
What is the the chlamydia national screening program (2003)
All individuals under 25 at each GP consultation should be offered an STI screen
What is first-line for chalmydia
Doxycycline
What is second-line for chlamydia
Azithromycin
Erythromycin if CI
When should individuals be re-tested following treatment
3m if under-25
What are 4 risks of chlamydia infection during pregnancy
- Stillbirth
- Miscarriage
- Pre-maturity
- Low birth weight
How do you treat chlamydia in pregnancy
Azithromycin
Why is azithromycin used to treat chlamydia in pregnancy
As doxycycline is CI