1: Digestive physiology of dogs and cats Flashcards

1
Q

The role of the digestive system is to…

A

break down large food molecules into simple forms that can be absorbed by the body for use

Also barrier function

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2
Q

What is a clinical sign if the GI tract is not working well

A

Diarrhea (secretory or malabsorptive)
Vomiting

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3
Q

Length of the GI tract of the dog vs the cat

What does intestinal length influence?

A

Dog
Body length = 0.75m
SI =3.9m
LI =0.6m

Cat
Body length = 0.5m
SI = 1.7m
LI = 0.4m

Length influences retention time of food in the gut

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4
Q

What are the structures used to increase capacity of the GI tract relative to body weight?

A

Coils, folds, villi, microvilli

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5
Q

Describe the GI tract of the dog

A
  • Monogastric GI system
  • Adapted to an omnivorous diet containing a high proportion of animal tissues
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6
Q

Starch digestion in cats vs dogs

A

Domestic dog has more capacity to digest starch (have amylase)
Cats have trouble digesting starch

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7
Q

Describe the cat GI tract

A
  • Monogastric GI system
  • Adapted to a carnivorous diet
  • Eat protein and fat, with some CHO found in animal tissues
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8
Q

Where is CHO found in animal tissues?

A

Glycogen is in muscle and liver, can be mobilized into glucose

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9
Q

What affects production of saliva by salivary glands? 4 pairs of glands:

A

Smell and presence of food stimulates the salivary gland to product saliva
- type of food ingested and its moisture content affect saliva amount and composition

glands: parotid, mandibular, sublingual and zygomatic

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10
Q

What is the role of saliva? What do dogs and cats lack in salivary glands that humans have?

A

Saliva aids with the mixing/chewing of food and lubrication before swallowing

Dogs and cats lack alpha-amylase (starch digestion is not initiated in the oral cavity)

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11
Q

Important function of saliva in dogs

A

Evaporative cooling

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12
Q

Describe teeth in dogs

A
  • cutting canine teeth for ripping and tearing
  • large molars and premolars can grind and chew large or tough pieces of food (more omnivorous = more chewing)
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13
Q

Describe teeth in cats

A
  • teeth are suited for holding and killing small prey animals
  • less efficient in chewing and grinding food
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14
Q

What is the esophagus? its role?

A
  • short, hollow, muscular tube
  • cell-lining produces mucus to help food passage
  • uses peristalsis to move the food
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15
Q

What is found at the base of the esophagus? Role?

A

The cardiac sphincter
- relaxation causes food to enter the stomach
- immediately closes again (prevents reflux of food from the stomach to the lower esophagus)

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16
Q

What is the stomach? Its roles?

A

A food reservoir

  • mixes food
  • regulates flow of digesta into the SI via a sphincter
  • initiates chemical digestion of protein (secretion of HCl and pepsinogen = protein unravels)

NO digestion of CHO and fats

17
Q

Sections of the stomach

A

Proximal and distal
Proximal expands during temporary food storage (allows dogs to eat discrete meals)

18
Q

What affects gastric secretions?

A
  • influenced by the amount of protein in the meal, the meal volume and hormones
  • gastric pH varies depending on the type of meal consumed (buffering capacity of the food)
19
Q

What controls the rate of gastric emptying? What is the role of soluble fibre in gastric emptying?

A
  • stomach volume, body weight, water intake and diet type
  • high density particles empty slower than smaller sized particles
  • hormonal control via macronutrient composition and characteristics

Soluble fiber decreases rate of gastric emptying

20
Q

Differences in the stomach of cats vs dogs

A

Stomach as storage reservoir is less important for cats than dogs
- Average half emptying times are 22 to 449 mins for cats vs. 72 to 240 mins for dogs
- stomach is simpler for cat than dog (smaller with smaller glandular fundus)

21
Q

What is the SI the primary site of? What happens to chyme

A

Site of chemical digestion and absorption of fat, starch, sugar, and protein

Acidic chyme moves from stomach into small intestine which stimulates secretion of pancreatic juice which increases the pH of the digesta.
Chyme is mixed with enzymes in the duodenum (which come from duodenal mucosa and pancreas)

22
Q

Functions of the pancreas

A

Exocrine: secretes enzymes and bicarbonate salts into the gut to establish optimal pH
- enzymes: inactive proteases, lipases and amylases

Endocrine: secrete hormones into the blood

23
Q

What do pancreatic juices of dogs have?

A

Antibacterial properties

24
Q

Which hormones are released by the pancreas and when?

A

Insulin released after a meal in dogs

Glucagon stimulates release of aa from muscle

25
What does the liver produce? What happens to it?
Bile Stored in gall bladder Released when chyme enters SI (GB contracts in response to food ingestion, emtpying peaks ~30min after meal) Function: emulsify dietary fat and activate enzymes to aid in fat digestion
26
Describe the dog/cat small intestine microbiology. What is it important for? When might bacteria overgrow?
Dog has simple microbial population Cat has more bacteria per unit of small intestine digesta, but dogs have more digesta Important to prevent colonization of pathogenic microbes Bacteria may overgrow with heat-(over)processed diets (poorly digested = more undigested residue as substrate)
27
Clear distinction between the small intestine of cats vs dogs
Cat: sugar transport systems are not adaptive to varying levels of dietary CHO Dog: sugar transport systems are highly adaptive to dietary CHO Slide 19
28
Pancreatic amylase production in cats
About 5% of that in dogs Relatively non-adaptive
29
How does a cat get blood glucose?
Gluconeogenesis (dietary protein into glucose) Glycogen
30
Functions, parts, transit time for large intestine
Functions: - absorption of water and electrolytes - fermentation of dietary fiber and undigested nutrients from the SI Parts: cecum, colon and rectum No villi on surface Transit time for dogs and cats approx 12h
31
Excreted feces are made up of what? Characteristics changed depending on...
Undigested food, sloughed cells and other endogenous losses, and bacteria Change depending on type of diet fed (amount of indigestible matter present)
32
Bacterial fermentation produces what?
Short chain fatty acids, lactate, CO2, hydrogen gas, and microbial protein Fiber used as energy source for bacteria which produce SCFA and microbial protein
33
Control of the GI tract
Nutrient flow: - from intestine to portal vein - Functions to control: enzymes, nutrient transporters, peristalsis Mechanisms - incretins (intestinal hormones) - Pancreas (pancreatic hormones, enzymes, bicarbonate) - nervous system
34
Slide 23
incretins
35
Stimulus for secretion and primary action of gastrin
Stimulus: peptides and aa's in stomach, distention of stomach Stimulates: secretion of gastric acid, pepsinogen and glucagon Inhibits: gastric emptying
36
Stimulus for secretion and primary action of CCK
Stimulus: peptides, aa's and fa's in duodenum Stimulates: pancreatic enzyme secretion and gall bladder contraction Inhibits: gastric emptying and secretion and relaxes sphincter of oddi
37
Outcome of the control of digested nutrients
- nutrient utilization and deposition - satiety - feed intake and feeding behaviour
38
Other control of food intake
- taste receptors - nutrient receptors