1. Definition of drug. Pharmacodynamics: Structure-dependent and independent drug actions Flashcards
Give the definition of ‘pharmacology’
Investigating the function-altering effect of several (exogenic and endogenic) substances in living entities.
Define pharmaceutical substances
If a substance can be used for treatment
Give the etymology of “Drug”
“Drug” (“droog” → “dry”)
What are pharmacodynamics?
The process of the drug entering the body
What are pharmacokinetics?
The interaction of the body on the drug
Which mnemonic is used to represent the pathway of the drug (pharmacodynamics)
ADME
“Corpora non agunt nisi fixata”
“A drug will not work unless it is bound”
Most drugs achieve their therapeutic effects by…
Interacting selectively with target molecules
- These play roles in physiologic or pathologic functioning
The selectivity of the drug binding may determine…
Adverse effects of a drug
Drug receptors are…
Macromolecules that, upon binding to a drug, mediate those biochemical and physiologic changes
Drugs binding to intracellular receptors
Highly lipophilic drugs that can easily pass through plasma membrane & also special barriers
Extracellular receptors
Surface protein receptors with extracellular domains linked to intracellular effector molecules
Which receptor types do drugs interact with?
- Ligand-gated ion channels
- G-protein coupled receptors
- Receptor-activated tyrosine kinases
- Intracellular nuclear receptors
Ligand-gated ion channels
Nicotinic ACh (nACh) receptors composed of 5 subunits
Give the area of the physiological function of nACh channels
- Neuromuscular junction
- Autonomic ganglia
- CNS
Give the function of the nACh receptor
- ACh binds to both α-subunits
- Channels open
- Na+ passes down its conc. gradient into cell
Give the types of nACh receptors (ligand-gated ion channels) involved in pharmacology
- Nm
- N<span>G</span>
Nm receptor - Area of function
Motor endplate of neuromuscular junctions of somatic nerves & skeletal muscles