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Question 1

Pt has prostate cancer. Hi serum ALP levels. you suspect mets. What marker would indicate liver metastasis rather than bone?

Answer 1

gamma-glutamyltransferase (GGT)

Question 2

hemineglect is most commonly associated with damage to this lobe

Answer 2

right parietal

Question 3

Personality disorder characterized by voluntary social withdrawal, limited emotional expression, and contentment in isolation (vs. avoidant).

Answer 3

Schizoid (think of an android)

Question 4

Personality disroder characterized by eccentric appearance, odd beliefs and magical thinking, interpersonal awkwardness.

Answer 4

Schizotypal

Question 5

Briefly describe the pathophysiology of hypersensitivity pneumonitis? What type of a hypersensitivity reaction is it?

Answer 5

Type III hypersensitivity reaction: IgG-actinomyces Ag complexes deposit in alveoli and bronchioles.

Question 6

What is the role of the Fas-FasL interaction?

Answer 6

FasL, expressed by cytotoxic T-lymphocytes induces apoptosis in cells expressing foreign Ag or autoreactive T-cells.

Question 7

What is the defective molecule in Marfan’s syndrome?

Answer 7

fibrillin, a component of the microfibril sheath that surrounds elastin fibers

Question 8

Where (at which particular body parts) is fibrillin expressed?

Answer 8

Zonular fibers (lens)
periosteum
aortic media

Question 9

What do Bordetella pertussis and Bacillus anthracis have in common with regard to their toxins?

Answer 9

Each has atoxin that is an adenylate cyclase that works by increasing intracellular cAMP and causing fluid buildup.

Question 10

Tx for acute arsenic poisoning?

Answer 10

chelation w/ Dimercaprol

Question 11

Side effects of dimercaprol?

Answer 11

nephrotoxicity and htn

Question 12

Most common source of arsenic poisoning?

Answer 12

arsenic-containing insecticides

Question 13

What is CaNa2EDTA used for?

Answer 13

Chelating agent for mercury and lead poisoning. It forms complexes w/ di- and tri-valent ions.

Question 14

What is the Tx for cyanide poisoning? how does it work?

Answer 14

Amyl nitrite. Forms Methemoglobin, which binds CN to form cyanomethemoglobin, which is non-toxic.

Question 15

Chelating agent for pts. receiving multiple blood transfusions.

Answer 15

Deferoxamine

Question 16

Tx for methemoglobinemia

Answer 16

methylene blue - reduces Fe3+ to Fe2+

Question 17

Nitroblue tetrazolium testing is for…

Answer 17

Chronic granulomatous disease (NAPDH deficiency)

Question 18

What is the deficiency in X-linked SCID?

Answer 18

IL-2 receptor defect

Question 19

What is the 2nd most common etiology of SCID?

Answer 19

adenosine deaminase deficiency

Question 20

What is the 3rd most common etiology of SCID?

Answer 20

Bare Lymphocyte Syndrome - failure to synthesize MHC II.

Question 21

What cofactor is necessary for formation of δ-ALA (heme synthesis p-way)?

Answer 21

pyridoxal phosphate (B6)

Question 22

What drug inhibits δ-ALA synthase?

Answer 22

isoniazid -> sideroblastic anemia

Question 23

Causes of acute pancreatitis (GET SMASHED).

Answer 23

Gallstones
Ethanol
Trauma
Steroids
Mumps
Autoimmune disease
Scorpion sting!
Hypercalcemia/Hypertriglyceridemia
ERCP
Drugs (e.g. sulfa)

Question 24

Pt. w/ acute epigastric abdominal pain radiating to the back, anorexia, and nausea.

Answer 24

Acute pancreatitis