Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Perio 2 2020 > 1/10/17 Systemic Antibiotics > Flashcards

1/10/17 Systemic Antibiotics Flashcards

1
Q

What two things are essential for periodontal disease to develop?

A
  • Microbial plaque

- Susceptible host

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the clinical benefits of chemotherapeutic agent?

A
  • Antimicrobial actions

- Ability to increase the hosts resistance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the three major categories of chemotherapeutics in periodontal treatment management?

A
  • Systemic antibiotics
  • Controlled drug delivery systems
  • Drugs that modulate host response
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

T/F

There is no evidence that antibiotics alone can arrest periodontal disease

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Should you give antibiotics to diabetic patients to help treat periodontal disease?

A

-Yes if they are uncontrolled If controlled treat them like they don’t have diabetes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What type of periodontitis can and should be treated initially without systemic antibiotics?

A

-Chronic periodontitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What type of periodontitis are antibiotics used to treat?

A

-Aggressive Periodontitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the initial therapy for chronic periodontitis?

A

-Scaling and Root planing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Antibiotics used in periodontal therapy are selected based on the what three things?

A
  • Microbial composition of the plaque
  • Patients medical status
  • Current medications
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

When taking a microbial sample what type of fluid do you place the sample in?

A

-RTF (Reduced Transport Fluid)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Periodontal disease is predominately what type of bacteria?
Gram +
Gram -

A

-Gram negative anaerobic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

T/F

Antibiotics should be used as a monotherapy in periodontal therapy

A

False

It should not be used as a monotherapy but should be part of a comprehensive treatment plan

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

When considering the use of antibiotics during periodontal therapy other than patients with aggressive periodontitis what other individuals should be considered?

A
  • Heavy Smokers
  • Immunocomporomised
  • Conjunction with some surgical procedures
  • Refractory periodontitis (High risk patients)
  • Necrotizing ulcerative periodontal disease
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

T/F

Penicillin is a commonly used antibiotics in periodontal therapy

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the mechanism of action of penicillins?

A

-Inhibit cell wall synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the spectrum of penicillins?

A

-Narrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is the effect of penicillins?

A

-Bacteriocidal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What are three frequently used penicillins (PCNs) used in periodontal therapy?

A
  • Amoxicillin
  • Pen VK
  • Amoxicillin with clavulanic acid (Augmentin)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

T/F

Tetracyclines are a commonly used antibiotic in periodontal therapy

A

True

20
Q

What is the mechanism of action of tetracyclines?

A

-Inhibit protein synthesis

21
Q

What is the spectrum of tetracyclines?

A

-Broad spectrum

22
Q

What is the effect of tetracyclines?

A

-Bacteriostatic

23
Q

What is an advantage of using tetracyclines?

A
  • Concentrates in the tissues
  • Destroys A.a.
  • Anticollagenase activity
24
Q

T/F

Tetracyclines increase photosensitivity in people

A

True

25
Q

What may happen to teeth when using tetracyclines?

A

-Causes discoloration

26
Q

What are two forms of tetracyclines used in periodontal therapy?

A
  • Doxycycline

- Minocycline

27
Q

Which form of tetracycline is easier on the stomach?

A

-Doxycycline

28
Q

Which form of tetracycline can you take with dairy products?

A

-Doxycycline

29
Q

T/F

Metronidazoles are commonly used antibiotics used in periodontal therapy

A

True

30
Q

What is the effect of metronidazoles?

A

-Bacteriocidal against anaerobic bacteria

31
Q

What is the mode of action of Metronidazole?

A

-Inhibits DNA synthesis by inserting itself into the DNA by blocking the ability of the gyrase

32
Q

T/F

Metronidazole is also anti-inflammatory

A

True

33
Q

What are five significant side effects from Metronidazole?

A
  • Antabuse
  • Metallic after taste
  • Discolor urine
  • Nausea & Vomiting
  • Peripheral neurophathy
34
Q

What type of antibiotic is very useful in treating subgingival plaque?

A

-Doxycycline because it concentrates in the tissue

35
Q

T/F

Clindamycin is an antibiotic used to treat periodontal disease

A

True

36
Q

What is the effect of Clindamycin?

A

-Bacteriostatic

37
Q

What is the spectrum of Clindamycin?

A

-Good anaerobic coverage

38
Q

What is the mode of action of Clindamycin?

A

-Inhibit protein synthesis

39
Q

What are two significant side effects of Clindamycin?

A
  • Skin rash

- Risk of pseudomembranous colitis due to over growth of Clostridium difficile

40
Q

T/F

Azithromycin is an antibiotic used to treat periodontal disease

A

True

41
Q

What is the effect of Azithromycin?

A

-Works against anaerobes and gram negative bacilli

42
Q

What is the mode of action of Azithromycin?

A

-Penetrates fibroblasts and phagocytes

43
Q

Where will you find higher concentrations of Azithromycin?

A

-Periodontal lesions as compared to normal gingiva

44
Q

What is the most common alternative to penicillin?

A

-Clindamycin

45
Q

What are two drugs that modulate host response?

A
  • NSAIDs

- Periostat

46
Q

What is the mechanism for Periostat?

A

-Anticollagenase activity

47
Q

When should you prescribe Periostat?

A

-Patients are high risk and appear to be non-responsive to conventional therapy

Perio 2 2020 (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions