[07] Semaglutide

Question 1

What are the brand names for Semaglutide?

Answer 1

• Ozempic
• Wegovy
• Rybelsus

Question 2

Who developed Semaglutide?

Answer 2

Novo Nordisk

Question 3

When was Semaglutide developed?

Answer 3

2012

Question 4

What is the primary use of Semaglutide?

Answer 4

• Type 2 diabetes
• Long-term weight management

Question 5

How is Semaglutide administered?

Answer 5

• Subcutaneous injection
• Orally

Question 6

What was Semaglutide’s rank in most prescribed medications in the U.S. in 2020?

Answer 6

129th

Question 7

How many prescriptions of Semaglutide were made in the U.S. in 2020?

Answer 7

Over 4 million

Question 8

For which condition is Semaglutide primarily indicated?

Answer 8

Type 2 diabetes

Question 9

For what other condition is higher-dose Semaglutide indicated?

Answer 9

Long-term weight management

Question 10

Who is eligible for Semaglutide weight management therapy?

Answer 10

• BMI ≥ 30 kg/m^2
• BMI ≥ 27 kg/m^2 with at least one weight-related comorbidity

Question 11

What kind of receptor agonist is Semaglutide?

Answer 11

GLP-1 receptor agonist

Question 12

GLP-1 - Initials

Answer 12

Glucagon-like Peptide-1

Question 13

How does Semaglutide affect insulin?

Answer 13

Increases production

Question 14

What other hormone does Semaglutide inhibit?

Answer 14

Glucagon

Question 15

What effect does Semaglutide have on appetite and digestion?

Answer 15

• Reduces food intake
• Lowers appetite
• Slows down digestion

Question 16

What is unique about Semaglutide’s chemical structure compared to human GLP-1?

Answer 16

• Missing first six amino acids of GLP-1
• Substitutions at GLP positions 8 and 34

Question 17

What enzyme does Semaglutide resist breakdown by?

Answer 17

Dipeptidyl peptidase-4

Question 18

What is the half-life of Semaglutide in the blood?

Answer 18

165-184 hours

Question 19

What are the common side effects of Semaglutide?

Answer 19

• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Constipation