[05] Liraglutide & Semaglutide

Question 1

What is the homology between Liraglutide and endogenous GLP-1?

Answer 1

97%

Question 2

Is Liraglutide resistant to DPP-4 degradation?

Answer 2

Yes

Question 3

What are the primary effects of Liraglutide?

Answer 3

• Stimulates insulin release
• Suppresses glucagon secretion

Question 4

How is Liraglutide administered?

Answer 4

Subcutaneous injection

Question 5

What is the half-life of Liraglutide?

Answer 5

Approximately 13 hours

Question 6

What is the dosing frequency of Liraglutide?

Answer 6

Once daily

Question 7

What is the BMI threshold for Liraglutide in weight management?

Answer 7

• ≥30 kg/m²
• ≥27 kg/m² with comorbidity

Question 8

What conditions is Liraglutide approved for?

Answer 8

• Diabetes management
• Chronic weight management

Question 9

What is the homology between Semaglutide and native GLP-1?

Answer 9

94%

Question 10

Is Semaglutide resistant to DPP-4 degradation?

Answer 10

Yes

Question 11

What is unique about Semaglutide’s duration of action?

Answer 11

Albumin-binding capacity

Question 12

How is Semaglutide administered?

Answer 12

• Subcutaneous injection
• Oral formulation

Question 13

What is the half-life of Semaglutide?

Answer 13

Approximately one week

Question 14

What enhances oral absorption of Semaglutide?

Answer 14

SNAC

Question 15

Is Semaglutide effective for type 2 diabetes?

Answer 15

Yes

Question 16

How does Semaglutide compare with other GLP-1 receptor agonists?

Answer 16

Superior in HbA1c and weight reduction

Question 17

What does DPP-4 stand for?

Answer 17

Dipeptidyl Peptidase-4

Question 18

What does BMI stand for?

Answer 18

Body Mass Index

Question 19

What does SNAC stand for?

Answer 19

Sodium N-(8-[2-hydroxybenzoyl] amino) caprylate

Question 20

What does HbA1c stand for?

Answer 20

Hemoglobin A1c