[04] GLP-1

Question 1

What is GLP-1?

Answer 1

Incretin hormone secreted from L-cells of the small intestine

Question 2

What is the primary trigger for GLP-1 secretion?

Answer 2

Nutrient ingestion

Question 3

Why is GLP-1 important?

Answer 3

Plays key roles in glucose homeostasis and energy balance

Question 4

Which metabolic diseases does GLP-1 impact?

Answer 4

• Type 2 diabetes mellitus
• Obesity

Question 5

What is the role of GLP-1 in insulin secretion?

Answer 5

Stimulates release from pancreatic beta cells

Question 6

Is insulin release from GLP-1 action glucose-dependent?

Answer 6

Yes

Question 7

How does GLP-1 affect glucagon secretion?

Answer 7

Inhibits it

Question 8

What is the impact of GLP-1 on gastric emptying?

Answer 8

Slows it down

Question 9

How does GLP-1 contribute to satiety?

Answer 9

Acts on central nervous system

Question 10

What is the origin of GLP-1?

Answer 10

Transcription product of the proglucagon gene

Question 11

What is the half-life of GLP-1?

Answer 11

Less than 2 minutes

Question 12

Which enzyme degrades GLP-1?

Answer 12

DPP-4

Question 13

What does GLP-1 stand for?

Answer 13

Glucagon-Like Peptide-1

Question 14

What does DPP-4 stand for?

Answer 14

Dipeptidyl Peptidase-4