[06] Liraglutide

Question 1

What is Liraglutide used for?

Answer 1

Treatment of type 2 diabetes and chronic obesity

Question 2

What are the brand names under which Liraglutide is sold?

Answer 2

• Victoza
• Saxenda

Question 3

How is Liraglutide administered?

Answer 3

Injection under the skin

Question 4

What are the common side effects of Liraglutide?

Answer 4

• Low blood sugar
• Nausea
• Dizziness
• Abdominal pain
• Pain at the site of injection

Question 5

Is Liraglutide a first or second-line therapy for diabetes?

Answer 5

Second-line, following metformin

Question 6

Does Liraglutide reduce cardiovascular risk in high-risk diabetes patients?

Answer 6

Yes, reduces risk for death from cardiovascular causes, nonfatal MI, or nonfatal stroke

Question 7

How does Liraglutide affect HbA1c levels?

Answer 7

Reduction of 0.24% more compared to insulin glargine

Question 8

Is Liraglutide recommended for weight management?

Answer 8

Yes, along with diet and exercise

Question 9

What kind of molecule is Liraglutide?

Answer 9

GLP-1 receptor agonist (also known as incretin mimetics)

Question 10

GLP-1 - Initials

Answer 10

Glucagon-like peptide-1

Question 11

How does Liraglutide affect insulin release?

Answer 11

Increases insulin release from the pancreas

Question 12

How does Liraglutide affect glucagon release?

Answer 12

Decreases excessive glucagon release

Question 13

What is the half-life of Liraglutide?

Answer 13

13 hours

Question 14

What is the half-life of endogenous GLP-1?

Answer 14

1.5-2 minutes

Question 15

DPP4 - Initials

Answer 15

Dipeptidyl peptidase-4

Question 16

NEP - Initials

Answer 16

Neutral endopeptidases

Question 17

What are the active forms of GLP-1?

Answer 17

• GLP-1-(7-36)NH2
• GLP-1-(7-37)

Question 18

How is the prolonged action of Liraglutide achieved?

Answer 18

By attaching a fatty acid molecule at one position of GLP-1-(7-37), enabling binding to albumin