06 - CBC Flashcards
3 main causes of decreased RBC
- hemolysis
- blood loss
- decreased production
3 causes of RBC hemolysis
- IMHA
- infectious
- zinc
5 causes of infectiuos causes of decreased RBC
- mycoplasma
- rickettsial
- babesiosis
- cytauxzoonosis
- heartworm
4 causes of decreased RBC due to decreased production
- anemia of chronic inflammatory disease
- decreased EPO (renal dz, hypothyroid, Addisons)
- infectious (FeLV, FIV, rickettsial)
- bone marrow dz (neoplasia, myelofibrosis, etc)
2 causes of increased red blood cells
- relative increase (dehydration, splenic contraction)
- physiologic increase (chronic lung disease, chronic cardiac disease)
Two causes of decreased MCV
- iron deficiency
- liver disease (PSS, liver failure)
two causes of increased MCV
- regenerative anemia
- felv infection
two causes of decreased MCH
- reticulocytosis
- iron deficiency (decreased hemoglobin production)
6 causes of normal reticulocytes in anemic patient
- chronic inflammatory disease
- lack of EPO (chronic renal disease, hypothyroid, addison’s)
- infectious (FeLV, FIV, rickettsial)
- liver disease/PSS
- iron def
- chronic blood loss
2 causes of increased reticulocytes in anemic patient
- blood loss (trauma, parasites, ruptured neoplasms, etc)
- hemolytic disease (IMHA, infectious, zinc)
3 main causes of decreased neutrophils
- decreased marrow production
- increased tissue demand (sepsis, viral, abscess)
- toxicity (estrogens, chemo)
two main causes of decreased neutrophils due to decreased bone marrow production
- infection (parvo, FeLV, toxo, rickettsial)
- neoplasia
2 causes of increased neutrophils
- inflammatory response (infectious, immune mediated, necrosis, neoplasia)
- steroid induced
What causes increased bands in neutrophils?
inflammatory response
4 Causes of decreased lymphocytes
- corticosteroid induced
- acute systemic inflammation (infection, endotoxemia)
- lymphangiectasia, PLE, GI lymphoma
- chylous effusion
4 Causes of increased lymphocytes
- epinephrine
- chronic antigenic stimulation
- addison’s
- lymphocytic neoplasia
1 cause of decreased monocytes
bone marrow disease
(can be a normal finding)
2 causes of increased monocytes
- inflammatory response
- steroid induced
1 cause of decreased eosinophils
- steroid induced
can be normal
2 causes of increased eosinophils
- parasitic infection
- allergic/hypersensitivity reaction
6 causes of increased eosinophils due to allergic/hypersensitivity
- asthma
- eosinophilic granuloma complex
- allergic dermatitis/atopy
- food allergies
- eosinophilic gastroenteritis
- allergic rhinitis/sinusitis
3 caues of increased nucleated RBC
- regenerative anemia
- splenic disease
- post-splenectomy
3 causes of decreased platelets
- artifact (clumping)
- decreased production (bone marrow suppression)
- consumption/destruction
immune mediated (severe)
non-immune (blood loss, DIC, local intravascular coagulation) (mild to moderate)