053 Pediatric Urologic Oncology: Renal and Adrenal

Question 1

__ is the most common extracranial solid neoplasm in children.

Answer 1

NEUROBLASTOMA is the most common extracranial solid neoplasm in children.

Question 2

Children __ of age or younger have a better survival rate than older children. This may be attributed to more favorable biologic parameters in tumors diagnosed at this age.

Answer 2

Children 18 MONTHS of age or younger have a better survival rate than older children. This may be attributed to more favorable biologic parameters in tumors diagnosed at this age.

Question 3

__ is curative for low-stage disease.

Answer 3

COMPLETE SURGICAL RESECTION is curative for low-stage disease.

Question 4

__, found in 20% of patients with primary tumors, is associated with tumor progression. This poor prognosis is independent of patient age and tumor stage. Additional biologic markers of poor prognosis have been defined and treatment protocols are currently based on these factors.

Answer 4

MYCN AMPLIFICATION, found in 20% of patients with primary tumors, is associated with tumor progression. This poor prognosis is independent of patient age and tumor stage. Additional biologic markers of poor prognosis have been defined and treatment protocols are currently based on these factors.

Question 5

Deletions of WT1, located on chromosome __, are found in patients with aniridia and Wilms tumor. Mutations of WT1 occur in DDS.

Answer 5

Deletions of WT1, located on chromosome 11p, are found in patients with aniridia and Wilms tumor. Mutations of WT1 occur in DDS.

Question 6

Local recurrence is increased in Wilms tumor patients with local tumor spillage, and this is now classified as stage __ disease. The 2- year survival rate after local recurrence is 43%.

Answer 6

Local recurrence is increased in Wilms tumor patients with local tumor spillage, and this is now classified as stage III disease. The 2- year survival rate after local recurrence is 43%.

Question 7

Patients with bilateral Wilms tumor should be treated with __. This will allow more patients to undergo renal sparing surgery in an attempt to decrease the risk of renal failure.

Answer 7

Patients with bilateral Wilms tumor should be treated with PREOPERATIVE CHEMOTHERAPY. This will allow more patients to undergo renal sparing surgery in an attempt to decrease the risk of renal failure.

Question 8

__ is the most common renal tumor in infants.

Answer 8

CONGENITAL MESOBLASTIC NEPHROMA (CMN) is the most common renal tumor in infants.